Tumor size may not be an accurate method of predicting lymph node involvement and disease progression in some breast cancers, according to investigators at the Research Institute of the McGill University Health Centre (MUHC). Their findings show that some types of breast tumors do not "play by the rules" and possibly, are more dangerous than previously believed.
"We have identified a group of breast cancer tumors that don’t conform to previous observations made in the general population of women with breast cancer," says MUHC geneticist and lead investigator, Dr. William Foulkes. "For these tumors there is only a very weak correlation between tumor size, the local spread of cancer cells and the likely severity of disease."
An associate professor in the Departments of Medicine, Human Genetics and Oncology at McGill University, Foulkes and his colleagues studied over 1500 women with breast cancer. Women with breast cancer who also had a mutation in particular gene, BRCA1, had unusual tumors. These tumors did not behave as expected - there was no clear correlation between tumor size and associated cancer in the axillary lymph nodes. This was not true for breast cancers in the general population, or those related to another breast cancer susceptibility gene, known as BRCA2.
Christine Zeindler | McGill University
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The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
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Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
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