Stem cell therapy for myocardial repair & regeneration
ESC Congress 2003
Heart attack and the resulting heart failure is still one of the leading causes of death in the western world. Therefore, new theraepeutical approaches to restore damaged heart tissue are indispensable. Prof. Hescheler’s research group has been working with murine embryonic stem cells for over 14 years now and was the first group worldwide to obviously measure physiological functions on embryonic stem cells.
Recently his group demonstrated that cardiac precursor cells, especially differentiated out of pluripotent embryonic stem cells and injected in infarcted heart tissue, are able to build up new functioning heart muscle tissue.
Embryonic stem cells can differentiate into nearly 200 different tissues. The main focus in his institute in Cologne is placed on the special development of so called cardiac precursor cells, “fore-runners” of differentiated, adult heart muscle cells. But how can we manage to lead many early embryonic stem cells on a physiological way to become fresh functioning heart cells?
For this reason many molecular biological steps are necessary, including some genetic “tricks”. At first a special protein-promotor is combined, which only works in cardiac precursor cells, with a green fluoescent protein, which stems from an atlantic jellyfish. If a cardiac precursor cell develops, this cell can be identifed by its green colour in the fluorescent microscope.
Furthermore to this “genetic double-construct” a gene is bound, which makes the cardiac precursor cells resistant against special antibiotics. If the antibiotics are then given into the cell suspension, only cardiac precursor cells survive.
In a mouse model a heart-attack-like damage by cryoinfarction is induced and the prepared cells injected into the infarcted area. After two weeks the heart is examined and wonderful green fluorescent tissue can be found, where before only dead material had been.
The physiological engraftment of the cells can be by different investigations such as echocardiography, heart-catheterization and many cellular processes. Even better: a significant benefit in the survival rate of infarcted and then cell-transplanted mice compared to animals without the transplantation can be proven.
Due to the promising results, the same will be performed on human embryonic stem cells. Prof. Hescheler’s group is one of three in Germany, found to be ethically sound and allowed by the government to import human embryonic stem cells for scientific purposes.
Professor Dr. med. Jürgen Hescheler
Institute of Physiology at the University of Cologne, Cologne
This press release accompanies both a presentation and an ESC press conference given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology
Camilla Dormer | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...