A gene present in nearly one in eight people is the most commonly inherited cancer susceptibility gene identified so far, increasing cancer risk in carriers by 26 percent, according to a study published by researchers at Chicagos Northwestern Memorial Hospital in todays Journal of Clinical Oncology. More common than the BRCA gene mutations, Transforming Growth Factor Beta Receptor 1*6A (TGFBR1*6A) may increase risk of breast cancer by 48 percent, ovarian cancer by 53 percent, and colon cancer by 38 percent.
"This is an exciting finding because TGFBR1*6A is a common gene that may cause a large number of cancers. In the near future, it will be commonplace for people to know what genes make them more susceptible to cancer, and well have many more options for preventing those cancers," says Boris Pasche, M.D., Ph.D., F.A.C.P., director of Northwesterns Cancer Genetics Program, assistant professor of medicine at the Feinberg School of Medicine and a researcher at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
Researchers analyzed seven published studies and pooled those results to conclude that the TGFRB1*6A gene may be to blame for approximately 7 percent of all breast cancers, nearly 11 percent of all ovarian cancers and 5.5 percent of all colon cancers, across a variety of ethnic groups. "These findings should put TGFBR1*6A on the map with better known cancer susceptibility genes such as BRCA1 and BRCA2 that have been implicated in an estimated 5 to 10 percent of all breast and ovarian cancers," said Dr. Pasche.
Altered genes trigger all cancer. "Most cases of breast, ovarian and colon cancers are caused by damage to the genes that builds up over a lifetime, but some people are born with a high risk of the disease," explains Pasche. "When inherited, the TGFRB1*6A gene makes people susceptible to having certain cells grow and divide uncontrollably, which may contribute to cancer development."
Amanda Widtfeldt | EurekAlert!
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Earth Sciences
25.04.2017 | Life Sciences
25.04.2017 | Earth Sciences