Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Carnegie Mellon develops new process for growing bone

14.08.2003


Researchers use new synthetic hydro-gel



Carnegie Mellon University’s Jeffrey Hollinger and his research team will receive $1.12 million over the next four years from the National Institutes of Health (NIH) to develop a new therapy for regenerating bone.

Bone, often called the structural steel and reinforced concrete of the human body, supports the body the way a steel framework supports a skyscraper, and it protects its vital organs the way a cast-concrete roof protects’ its building occupants. "Unfortunately, bone loss is an unavoidable consequence of aging, osteoporosis and many traumatic accidents,’’ Hollinger said.


To address the challenges of safe and effective therapy to restore form and function to deficient bone architecture, Hollinger’s research team at Carnegie Mellon’s Bone Tissue Engineering Center has developed an innovative therapy for growing bone by inserting a non-viral gene into the body to induce cells to grow bone.

"We are injecting the NTF gene into a site where bone is deficient via a synthetic hydro-gel made from a hyaluronic acid-based polymer,’’ Hollinger said. "The hydro-gel/NTF is non-immunogenic and is designed to restore form and function to bone deficiencies.’’

Some of the first pre-clinical trials will involve growing bone in the jaw, said Hollinger. And according to transportation officials, about 10 percent of vehicle accident injuries involve the jaw and the flat bones in the face. "Restoring periodontal bone loss is a high priority for our team, and Bruce Doll, head of the Department of Periodontology at the University of Pittsburgh is leading this challenge,’’ Hollinger said.

Through ever-improving surgical techniques, the replacement of bone has been done via bone grafting either from the patient’s own body or from animal (usually cow) bone. But because the human body is inclined to reject most ’non-self’ grafts, Hollinger’s synthetic approach to growing bone will eliminate immune rejections. His research team includes Doll at the University of Pittsburgh’s Dental School and Carnegie Mellon Bone Tissue Engineering Center scientists Yunhua Hu and Huihua Fu, the two scientists who perfected the NTF-hydrogel therapy, and whose work was the foundation for the NIH grant. .

In addition to growing bone for injuries to the jaw, Hollinger’s research team plans to use the new bone regeneration process to treat osteoporotic fractures, and in other applications in other pasrts of the body including the spine, pelvis and all powerful thigh bone – about 20 inches long and more than an inch across at the midshaft. A mature body contains more than 600 muscles and 206 bones, not counting the tiny seasmoid bones – like sesame seeds – embedded in the tendons of the thumb, big toe and other pressure points.

"After blood, bone is the most frequently transplanted tissue. Current therapies for bone grafting fall short of the mark. The Bone Tissue Engineering Center is developing exciting new bone theraputics that will offer surgeons and their patients much better options. And the NTF/injectable hydrogel is one such example therapy from the Carnegie Mellon-Pitt team,’’ Hollinger said.

Chriss Swaney | EurekAlert!
Further information:
http://www.cmu.edu/

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>