Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Epitope plays a key role in the development of rheumatoid arthritis

16.07.2003


Rheumatoid arthritis is a chronic inflammatory disease characterized by joint destruction. It has been suggested that the extracellular matrix protein osteopontin (OPN), which is expressed by a number of different mediators of the immune response, may facilitate this destruction.



In the July 15 issue of The Journal of Clinical Investigation, Nobuchika Yamamoto and colleagues from the Fujisawa Pharmaceutical Company in Japan, provide important new evidence indicating a role for OPN in the pathogenesis of inflammatory arthritis and associated joint destruction.

OPN is abundant in bone, where it facilitates cell adhesion and modulation of the immune response. This adhesion is facilitated by interaction with a variety of cell surface molecules known as integrins. Binding of OPN to these cell surface molecules generally occurs at a specific integrin-binding motif. A second sequence, (SLAYGLR in mice and SVVYGLR in humans) within OPN has also been shown to mediate this cell adhesion. The site is the result of cleavage of human OPN by the protease thrombin and promotes the adherence of cells expressing intergrins a4 and a9.


In their latest report, Yamamoto and colleagues observed that monocytes of arthritic mice had a greater tendency to migrate toward thrombin-cleaved OPN, than full-length OPN, and that these monocytes expressed integrins a4 and a9 that bind the SLAYGLR epitope. Furthermore, the authors demonstrated that antibody blockade of the SLAYGLR sequence stopped monocyte migration to the cleaved OPN and significantly suppressed the development of arthritis in mice. The study indicates the critical role of the SLAYGLR sequence in the pathogenesis of rheumatoid arthritis in mice.

"The effects on the clinical and histologic parameters studied provide convincing additional evidence for a role of OPN in arthritic inflammation, and specifically in the recruitment of inflammatory cells to arthritic joints" stated Dr. Ellen Gravallese from Beth Israel Deaconess Medical Center and Harvard Institutes of Medicine in her accompanying commentary. She continues "given the clear and important role of OPN in inflammatory processes and bone remodeling, it will be of considerable interest to resolve some of the remaining controversies regarding the role of OPN in this disease".

Contact:

Nobuchika Yamamoto
Exploratory Research Laboratories,
Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Phone: 81-029-847-8611
Fax: 81-029-847-1536
Email: nobuchika_yamamoto@po.fujisawa.co.jp

Brooke Grindlinger | EurekAlert!
Further information:
http://www.jci.org

More articles from Health and Medicine:

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

nachricht Improving memory with magnets
28.03.2017 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Periodic ventilation keeps more pollen out than tilted-open windows

29.03.2017 | Health and Medicine

Researchers discover dust plays prominent role in nutrients of mountain forest ecoystems

29.03.2017 | Earth Sciences

OLED production facility from a single source

29.03.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>