Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study suggests HPV16 can skirt the immune system

16.07.2003


Human papillomavirus 16 (HPV16), the virus responsible for approximately half of all cervical cancers, appears to be better at dodging the immune system than other HPV types, according to a large study of HIV-positive women in the July 16 issue of the Journal of the National Cancer Institute. The findings may help explain why HPV16 plays such a major role in causing cervical cancer in the general population.

Whereas other HPV types have a lower prevalence and incidence among women with stronger immune systems (in theory, the stronger the immune system, the better it is at fighting off infections), researchers detected similar levels of HPV16 in women with both weak and strong immune systems.

More than 30 types of HPV are known to infect the genital epithelium. HPV16 has been the strain most strongly associated with cervical cancer and its precursor lesions. What sets HPV16 apart from other HPV types has not been clear. A preliminary analysis of a study on HPV infection among women positive for HIV, the virus that causes AIDS, suggested that HPV16 may be less associated with immune status than other HPV types.



To confirm this theory, Howard D. Strickler, M.D., and Robert D. Burk, M.D., of the Albert Einstein College of Medicine in Bronx, N.Y., and their colleagues compared the prevalence and incidence of different HPV types among HIV-positive women with varying levels of T cells, an indicator of immune status.

The final analysis included 2,058 HIV-positive women from the Women’s Interagency Human Immunodeficiency Virus Study and 871 HIV-positive women from a separate HIV Epidemiology Research Study. The women were examined during repeat study visits where cervical tissue samples were collected and HPV-type analysis was performed.

The researchers found that the prevalence ratio for HPV16, calculated by comparing prevalence rates of each HPV type for women with low versus high T-cell count, was low compared with that of other HPV types at every visit in both cohorts, suggesting that HPV16 is less influenced by the immune system than other HPV types.

In fact, the summary prevalence ratio for HPV16 was statistically significantly lower than that of all other HPV types combined. The incidence of HPV16 was also less associated with T-cell count than the incidence of other HPV types.

"The predominance of HPV16 in cervical disease in the general population might be explained partly by its ability to avoid immune clearance and the effects that this avoidance might have on the frequency and duration of infection," the authors write.

They say that the results of this study raise a number of testable hypotheses. "If it is true that the major etiologic risk factor for cervical cancer, HPV16, is not strongly affected by immune status, this fact could also help explain why cervical cancer rates appear to be only moderately increased in HIV/AIDS-affected women compared with HIV-seronegative women," they write.

Similarly, the use of highly active antiretroviral therapy (HAART) to improve immune status might only have a moderate effect on lowering an HIV-positive woman’s risk of developing precancerous lesions and cervical cancer. "We predict that the use of HAART in HIV-seropositive women will reduce the incidence, duration, and progression of cervical lesions, but that its effect will be less on lesions related to HPV16 than on those related to other HPV types," the authors say.

They add that additional studies should be able to address these predictions.

Contact:
Karen Gardner
Albert Einstein College of Medicine
Fon 001 - 718-430-3101
Email: kgardner@aecom.yu.edu

Linda Wang | EurekAlert!

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>