Researchers at the Duke Comprehensive Cancer Center have demonstrated a new way to target and choke off the blood supply to cancerous liver tumors in mice. The new method inhibited liver tumor growth and extended survival in mice by blocking a receptor on blood vessel endothelial cells that triggers blood vessel growth. Blocking this "Tie2" receptor worked as well as or better than naturally occurring proteins that inhibit blood vessel growth in tumors, the study showed.
The new study comes on the heels of a June 2003 report from Duke that a new drug, Bevacizumab (trade name Avastin), shrinks tumors and extends survival in patients with colorectal cancer that has spread. Spreading cancer is called "metastatic" cancer, and it is particularly deadly when it reaches the liver. More than 75 percent of colon cancer patients die as a direct result of metastases to the liver, so finding new ways to inhibit liver tumor growth is extremely important, said the Duke researchers.
Bevacizumab and the new treatment approach both work by blocking tumor angiogenesis, the process by which tumor cells grow new blood vessels. Bevacizumab inhibits a protein called vascular endothelial growth factor (VEGF), which malignant cells secrete in order to grow and maintain their blood vessels. When VEGF is blocked by bevacizumab, the tumors blood supply is diminished and the tumor shrinks and slows its spread.
Becky Levine | DUMC
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17.11.2017 | National Institute of Standards and Technology (NIST)
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The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
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17.11.2017 | Studies and Analyses