Researchers at the Duke Comprehensive Cancer Center have demonstrated a new way to target and choke off the blood supply to cancerous liver tumors in mice. The new method inhibited liver tumor growth and extended survival in mice by blocking a receptor on blood vessel endothelial cells that triggers blood vessel growth. Blocking this "Tie2" receptor worked as well as or better than naturally occurring proteins that inhibit blood vessel growth in tumors, the study showed.
The new study comes on the heels of a June 2003 report from Duke that a new drug, Bevacizumab (trade name Avastin), shrinks tumors and extends survival in patients with colorectal cancer that has spread. Spreading cancer is called "metastatic" cancer, and it is particularly deadly when it reaches the liver. More than 75 percent of colon cancer patients die as a direct result of metastases to the liver, so finding new ways to inhibit liver tumor growth is extremely important, said the Duke researchers.
Bevacizumab and the new treatment approach both work by blocking tumor angiogenesis, the process by which tumor cells grow new blood vessels. Bevacizumab inhibits a protein called vascular endothelial growth factor (VEGF), which malignant cells secrete in order to grow and maintain their blood vessels. When VEGF is blocked by bevacizumab, the tumors blood supply is diminished and the tumor shrinks and slows its spread.
Becky Levine | DUMC
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Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.
Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...
Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.
Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...
With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
30.09.2016 | Event News
29.09.2016 | Event News
28.09.2016 | Event News
30.09.2016 | Materials Sciences
30.09.2016 | Earth Sciences
30.09.2016 | Life Sciences