Pretreating transplanted livers with the immune molecule interleukin-6 (IL-6) dramatically increased survival of rats receiving organs with fatty degeneration--a common condition in humans that typically reduces transplant viability. The results suggest a means of making it possible to use a higher percentage of available donor livers for transplantation in humans. With over three times as many Americans needing transplants as there are available donor livers, an effective approach to increasing the number of viable donor organs would help narrow the gap between demand and supply.
Steatosis, or fatty liver degeneration, is present in between 13 and 50 percent of donor livers. Fat may accumulate in the liver in association with obesity, diseases such as diabetes mellitus, and heavy drinking. Donor livers with steatosis are more likely to function poorly or fail after transplantation. With the increase in obesity in this country, the prevalence of steatosis in donor livers is expected to increase. A multi-center team of scientists found that adding the cytokine or cell-signaling molecule interleukin-6 (IL-6) to the solution in which a donor liver is stored before transplantation significantly increases post-transplant survival of rats receiving organs with fatty degeneration. Bin Gao, M.D., Ph.D., at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), led the scientific team which included investigators at The Johns Hopkins University School of Medicine, Baltimore, MD (supported in part by a research grant from NIH’s National Institute on Diabetes and Digestive and Kidney Diseases) and the University of Science and Technology of China, Hefei, China.
NIAAA Director Ting-Kai Li, M.D. said, "This study is an example of how our knowledge at a molecular level of how the immune system functions to protect against tissue damage can be exploited to develop strategies for dealing with important clinical problems. The work gives us a clue for future treatment and enhances our understanding of the mechanisms of liver damage, and the protection afforded by IL-6, after transplantation."
Ann Bradley | EurekAlert!
New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia
New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences