Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

3D mammography shows promise as next breast screening technique

08.05.2003


“Full-field digital tomosynthesis is mammography--only better,” researchers say of a new technique that just might be the next generation of breast cancer screening. Two new studies on this technique illustrate that full-field digital tomosynthesis (TOMO) can not only increase the visibility of breast lesions but could likely dramatically reduce the number of patients being called back for a second mammogram because their first screening mammogram was unclear.



In the first study, researchers compared standard plain film mammography to TOMO. Forty patients were included in the study. Radiologists detected 16 of 22 malignant lesions on mammography and 18 of 22 malignant lesions on TOMO, says Elizabeth Rafferty, MD, lead author of both studies. TOMO was superior to plain film mammography in detecting masses and architectural distortions, which results from a tethering or pulling in of the tissue, says Dr. Rafferty. Calcifications were not as conspicuous on the tomosynthesis imaging during the pilot study, she says. “We are currently implementing a solution to this challenge and will have data on this soon,” she adds.

In the second study, 45 patients were reviewed. All patients had been called back for a second mammogram because their first showed a possible abnormality; “30 of them were subsequently found by additional mammographic views to have breast tissue overlap accounting for their possible abnormality,” she says. Fifteen patients went on to biopsy. “We asked radiologists to look at the TOMO study (without knowing the results of the second mammogram or biopsy) and indicate whether they would have called these patients back for additional evaluation,” says Dr. Rafferty. They indicated that they would have only called back five of the 30 patients who had breast tissue overlap. “If we could have used TOMO on these patients initially, it would have saved 25 women the anxiety they felt and the inconvenience they experienced of being called back for additional tests,” notes Dr. Rafferty.


The radiologists indicated that they would have recalled 14 of the 15 patients who had a biopsy, says Dr. Rafferty. A single reader missed one cancer, she says. “This is well within the standard interobserver variability seen with conventional mammography,” she adds.

“TOMO allows us to take multiple projections of the breast at different angles. These projections are then reconstructed into a three-dimensional data set. We can then look at each slice individually and assess each area of the breast without confusing overlap from surrounding structures,” Dr. Rafferty says. “The ability to look at individual slices of the breast is a real asset,” she says.

TOMO is more comfortable for the patient. The patient’s breasts only need to be compressed once (compared to twice for the standard two-view mammogram); the patient sits during the procedure, and the overall radiation dose is lower, says Dr. Rafferty. Dr. Rafferty cautions, however, that “full-field digital tomosynthesis is still in its infancy.” However, she predicts, “this technique will only get better.” Researchers at Massachusetts General Hospital conceived, developed, and patented full-field breast tomosynthesis, and, in conjunction with General Electric, built the only prototype currently in clinical use. To date, more than 350 clinical tomosynthesis studies have been performed at Massachusetts General Hospital under research protocols.


Dr. Rafferty will present the results of her studies on May 8 during the American Roentgen Ray Society Annual Meeting in San Diego.

Contact: Keri J. Sperry (703) 858-4306
Danica Laub (703) 858-4332
Press Room: (619) 525-6536 (May 5-8)

Keri Sperry | EurekAlert!
Further information:
http://www.arrs.org/

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>