Acetaminophen, the medicine in Tylenol®, clears rapidly and completely from the bloodstream even in doses as high as twice the daily recommended dose, according to new research presented at the 42nd annual meeting of the Society of Toxicology recently in Salt Lake City.
"Our objective was to take what we already knew about the pharmacokinetics of acetaminophen and go a step further," explained lead investigator Cathy K. Gelotte, PhD, Executive Director, Medical and Regulatory Product Development, McNeil Consumer & Specialty Pharmaceuticals. "We wanted to see if acetaminophen is cleared at the same rate when we increased dosage beyond the recommended maximum adult daily dose of 4 g/day to 8 g/day. This study demonstrates how the body handles a higher dose and may be useful data for physicians."
The study, a double-blinded, placebo-controlled design, examined the pharmacokinetics of three dosing regimens: 4 g/day, 6 g/day, and 8 g/day. A total of 36 subjects were divided into two groups. Group I included 6 patients on placebo and 12 on acetaminophen taking 4 g/day then 6 g/day. Group II included 6 patients on placebo and 12 patients on acetaminophen taking 4 g/day then taking 8 g/day. Regimens were continued for three consecutive days, with blood sampling during the first and last dose of each daily regimen.
Robert Murphy | EurekAlert!
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Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
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