Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research shows high doses of acetaminophen clear rapidly and consistently from bloodstream

02.04.2003


Acetaminophen, the medicine in Tylenol®, clears rapidly and completely from the bloodstream even in doses as high as twice the daily recommended dose, according to new research presented at the 42nd annual meeting of the Society of Toxicology recently in Salt Lake City.



"Our objective was to take what we already knew about the pharmacokinetics of acetaminophen and go a step further," explained lead investigator Cathy K. Gelotte, PhD, Executive Director, Medical and Regulatory Product Development, McNeil Consumer & Specialty Pharmaceuticals. "We wanted to see if acetaminophen is cleared at the same rate when we increased dosage beyond the recommended maximum adult daily dose of 4 g/day to 8 g/day. This study demonstrates how the body handles a higher dose and may be useful data for physicians."

The study, a double-blinded, placebo-controlled design, examined the pharmacokinetics of three dosing regimens: 4 g/day, 6 g/day, and 8 g/day. A total of 36 subjects were divided into two groups. Group I included 6 patients on placebo and 12 on acetaminophen taking 4 g/day then 6 g/day. Group II included 6 patients on placebo and 12 patients on acetaminophen taking 4 g/day then taking 8 g/day. Regimens were continued for three consecutive days, with blood sampling during the first and last dose of each daily regimen.


"Analysis of plasma acetaminophen levels showed that doses as high as 8 g/day, or twice the maximum daily recommended dose, did not accumulate and the drug was consistently cleared from the bloodstream," said Dr. Gelotte. "Moreover, it is important to note that liver enzyme values for all subjects, regardless of whether they were on the 4-, 6-, or 8 g/day regimen, stayed within normal limits throughout the study."

Dr. Gelotte emphasized that this study was undertaken to learn more about the pharmacokinetic profile of acetaminophen. It was not intended to explore the potential for increasing the recommended daily dosage of acetaminophen.

"It is important that consumers continue to adhere to the recommended daily dosage of no more than 4 g of acetaminophen per day, as listed on the product label," said Dr. Gelotte.

The research was conducted by McNeil Consumer & Specialty Pharmaceuticals, a division of McNeil-PPC, Inc., headquartered in Ft. Washington, PA that markets products such as Tylenol®, Imodium®, St. Joseph®, Concerta® (methylphenidate) for ADHD and Motrin®.

Robert Murphy | EurekAlert!
Further information:
http://www.djstorch.com

More articles from Health and Medicine:

nachricht Chronic stress induces fatal organ dysfunctions via a new neural circuit
21.08.2017 | Hokkaido University

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Nagoya physicists resolve long-standing mystery of structure-less transition

21.08.2017 | Materials Sciences

Chronic stress induces fatal organ dysfunctions via a new neural circuit

21.08.2017 | Health and Medicine

Scientists from the MSU studied new liquid-crystalline photochrom

21.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>