Acetaminophen, the medicine in Tylenol®, clears rapidly and completely from the bloodstream even in doses as high as twice the daily recommended dose, according to new research presented at the 42nd annual meeting of the Society of Toxicology recently in Salt Lake City.
"Our objective was to take what we already knew about the pharmacokinetics of acetaminophen and go a step further," explained lead investigator Cathy K. Gelotte, PhD, Executive Director, Medical and Regulatory Product Development, McNeil Consumer & Specialty Pharmaceuticals. "We wanted to see if acetaminophen is cleared at the same rate when we increased dosage beyond the recommended maximum adult daily dose of 4 g/day to 8 g/day. This study demonstrates how the body handles a higher dose and may be useful data for physicians."
The study, a double-blinded, placebo-controlled design, examined the pharmacokinetics of three dosing regimens: 4 g/day, 6 g/day, and 8 g/day. A total of 36 subjects were divided into two groups. Group I included 6 patients on placebo and 12 on acetaminophen taking 4 g/day then 6 g/day. Group II included 6 patients on placebo and 12 patients on acetaminophen taking 4 g/day then taking 8 g/day. Regimens were continued for three consecutive days, with blood sampling during the first and last dose of each daily regimen.
Robert Murphy | EurekAlert!
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Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
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