Antibody/enzyme combo protects transplanted lungs from oxidative stress damage
Protecting endothelial cells with targeted antioxidant enzymes (AOE). The AOE, catalase in this case, connected to an antibody binds to endothelial cells (EC) and detoxifies reactive oxygen species (ROS), which can cause free radical damage.
Researchers based at the University of Pennsylvania School of Medicine have combined the precision of antibodies with the power of an antioxidant enzyme to create a new way to protect transplanted lungs from oxidative stress – also known as free radical damage – before and during transplantation.
Their findings, presented in the April edition of Nature Biotechnology and available online now, demonstrate the therapeutic potential of immunotargeting as a drug delivery system. Oxidative stress causes some degree of damage in 15-20% of all transplants and is the leading cause of acute lung graft failure. By protecting the lungs from damage, the researchers have determined that they can increase lung-graft survivability and the length of time a donated lung can be kept in cold storage.
Greg Lester | EurekAlert!
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