Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Six-week, six-shot regimen fights hayfever for more than one season

12.03.2003


Johns Hopkins researchers last year reported that an experimental treatment for severe ragweed allergy consisting of just six shots in six weeks dramatically reduced allergic symptoms such as runny nose, nasal congestion and sneezing, and nearly eliminated the need for relief medications like antihistamines and decongestants. Now, follow-up of patients who continued in the study for a second year, shows that the initial six-injection course of this treatment appears to be effective – and safe – for more than one allergy season.



"We are particularly pleased that this brief, six-week, six-injection regimen can have lasting positive effects for more than one season of ragweed exposure," said Peter Creticos, M.D., associate professor of medicine at Johns Hopkins and principal investigator of the study. "These studies represent a major advance in the development of new treatments for allergic disease, especially when compared with conventional allergy treatments, which can take years to be effective," he added.

The new treatment is an allergy vaccine created by attaching immune-system-boosting molecules, or oligonucleotides, to Amb 1 a, the major ragweed protein responsible for allergic reactions.


Creticos will present the new findings of the Johns Hopkins study on March 11 at a special symposium on "Allergy Therapeutics" at the 60th annual meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI).

The observer-blinded, placebo-controlled Phase II study evaluated adult volunteers who had a history of fall seasonal hayfever and had skin test reactions to ragweed pollen. Using a vaccine developed by scientists at University of California, San Diego, and produced by Dynavax Technologies Corporation of Berkeley, Calif., Johns Hopkins investigators gave patients the new treatment before the 2001 ragweed season. These patients were followed for their clinical improvement throughout the 2001 and 2002 ragweed seasons – without additional injections of the vaccine.

The follow-up phase of the study showed that patients given the vaccine had improved hayfever symptoms, quality of life measurements, and less need for relief medications during the second ragweed season and these changes were similar to those observed during the initial ragweed season.

Other investigators in the study are Joseph Eiden, David Broide, Susan Balcer-Whaley, John Schroeder, Arouna Khattignavong, Huamin Li, Philip Norman and Robert Hamilton.

This research was performed as part of the Immune Tolerance Network, with support from the National Institute of Allergy and Infectious Diseases, the National Institute of Diabetes and Digestive and Kidney Diseases, and the Juvenile Diabetes Research Foundation.


Dr. Creticos is a paid consultant to Dynavax Technologies. Another member of the JHU Division of Clinical Immunology is a paid consultant to and owns equity in the company

Trent Stockton | EurekAlert!
Further information:
http://www.hopkinsmedicine.org/
http://www.hopkinsmedicine.org/press/2002/MARCH/020302.htm
http://www.hopkins-allergy.org/

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

Researchers invent process to make sustainable rubber, plastics

25.04.2017 | Materials Sciences

Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017

25.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>