Mayo Clinic researchers have proven for the first time that cells produced by the bone marrow can form new heart-muscle cells in adults, providing an important boost to research that could enable the body to replace heart muscle damaged by heart attack. The findings are now available online and will be published tomorrow in Circulation: Journal of the American Heart Association.
"Until recently, the heart has been seen as an organ that cannot be healed," says Noel Caplice, M.D., the Mayo Clinic cardiologist who led the study. "Heart-attack damage to the myocardium, or heart muscle, was considered irreversible. This study points the way to a process that could lead to heart repair."
The researchers studied four female patients with leukemia who had survived 35 to 600 days after receiving bone-marrow transplants from male donors. Heart tissue samples were examined at autopsy using special staining techniques, which showed that a small portion of the heart-muscle cells, or cardiomyocytes, contained male genetic material and had therefore originated from the donor marrow. Of the more than 80,000 cell nuclei examined, about 1 in 425 (.23 percent) contained the y chromosome.
Lee Aase | EurekAlert!
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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