The JNK signaling pathway allows cells to respond to changes in their extracellular environment and in doing so, controls many aspects of cell function including cell proliferation, differentiation and death. Studies have also shown that this pathway plays a role in cancer, although it has been unclear whether active JNK signaling can accelerate or protect cells from becoming cancerous. Several studies using cultured cells have suggested that JNK signaling may be important for promoting tumor cell development, while studies of tumors from human patients have indicated that JNK signaling may act to suppress tumor development.
Dr. Davis and colleagues set out to address the role of JNK signaling in tumor formation using cells from mice that have been engineered to be deficient in JNK signaling. They demonstrated that in vitro, JNK signaling does indeed play a role in transforming normal cells into those displaying the characteristics of tumor cells.
However, when they moved their experiments into a mouse model of tumor development, it was clear that JNK signaling is not required for tumor formation. In fact, the scientists actually found the opposite - that the absence of JNK signaling resulted in a dramatic increase in the number and growth of tumors when compared to control animals. This result suggests that in vivo, JNK signaling acts to suppress tumor development.
Michele McDonough | EurekAlert!
Advanced analysis of brain structure shape may track progression to Alzheimer's disease
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Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.
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Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
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In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
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