The JNK signaling pathway allows cells to respond to changes in their extracellular environment and in doing so, controls many aspects of cell function including cell proliferation, differentiation and death. Studies have also shown that this pathway plays a role in cancer, although it has been unclear whether active JNK signaling can accelerate or protect cells from becoming cancerous. Several studies using cultured cells have suggested that JNK signaling may be important for promoting tumor cell development, while studies of tumors from human patients have indicated that JNK signaling may act to suppress tumor development.
Dr. Davis and colleagues set out to address the role of JNK signaling in tumor formation using cells from mice that have been engineered to be deficient in JNK signaling. They demonstrated that in vitro, JNK signaling does indeed play a role in transforming normal cells into those displaying the characteristics of tumor cells.
However, when they moved their experiments into a mouse model of tumor development, it was clear that JNK signaling is not required for tumor formation. In fact, the scientists actually found the opposite - that the absence of JNK signaling resulted in a dramatic increase in the number and growth of tumors when compared to control animals. This result suggests that in vivo, JNK signaling acts to suppress tumor development.
Michele McDonough | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy