Dartmouth researchers report in the March 1 issue of Cancer Research they have discovered an effective combination therapy to treat tumors. In the journal, which is a publication of the American Association for Cancer Research, the researchers report that administering light-activated, or photodynamic, therapy (PDT) immediately before radiation therapy appears to kill tumors more effectively than just the sum of the two treatments.
"Our study shows that the close combination of the two treatments complement each other, allowing more effective therapy for the same delivered dose," says Brian Pogue, the lead author, an Associate Professor at Dartmouths Thayer School of Engineering and a Research Scientist at Harvard Medical School.
PDT is used to treat a variety of illnesses, from lung cancer to age-related blindness. The treatment uses a light-activated drug to kill tumor tissue. The drug, verteporfin in this study, is designed to accumulate within tissues with tumor-like characteristics, such as leaky vasculature and rapidly growing cells.
Sue Knapp | EurekAlert!
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