Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Time to Go Beyond Cholesterol, MUHC Cardiologists Suggest


There is a better way to determine risk of heart disease than measuring cholesterol, according to a new study by cardiologists from the Research Institute of the McGill University Health Centre (MUHC). This study shows that measuring the amount of a protein called apoprotein B or apoB, is a more accurate and efficient test than measuring cholesterol. These findings will be published in the March issue of the international journal, The Lancet.

ôThe tradition in clinical practice is to look at the levels and ratios of cholesterol as predictors of cardiovascular disease, ö says Dr. Allan Sniderman, MUHC cardiologist and first author of the study. ôBecause this test has its limitations we decided to look at other possibilities. This study shows that apoB is a more robust indicator of a cardiac events and we suggest that it is superior to looking just at cholesterol levels.ö

Sniderman and colleagues from Australia, British Columbia, Sweden and The Netherlands, analyzed data from epidemiological studies and clinical trials involving thousands of heart patients. Their overwhelming conclusion was that, although measuring levels of cholesterol is a good start, it is not enough. ôWhen we looked at data from patients who had their cholesterol levels lowered using medications, we found that their apoB levels were still high. This suggests that these patients are still at risk of having a heart attack. This is a concern because according to the cholesterol results, the patient was adequately treated,ö says Dr. Sniderman.

Because apoproteins can be accurately and inexpensively measured in routine clinical laboratories, we suggest that this measurement should be brought into clinical practice. In addition, this test is considerably more convenient to the patients because fasting is not required, ô concludes Dr. Sniderman.

Apoproteins are specialized transport proteins that carry lipids, or fats in the blood. Most of the cholesterol in blood is present in low-density lipoprotein (LDL) particles. Each LDL particle contains one molecule of apoB, which surrounds and stabilizes it. LDL particles differ in size depending on how much cholesterol they contain. The smaller LDL particles have less cholesterol, but are associated the most with coronary artery disease and are more dangerous to have circulating in the blood than the larger LDL molecules that contain more cholesterol. An increased number of LDL particles in the blood will lead to a greater risk of heart attacks or strokes. Lowering LDL particle number is the most powerful method now available to lowering the risk of heart attacks.

For more information, please contact:
Christine Zeindler, MSc
Communications Coordinator (Research)
McGill University Health Centre Communications Services

(514) 934-1934 ext. 36419
pager: (514) 406-1577

Christine Zeindler | MUHC Communications

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>