Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Leptin regulates the immune response to friend and foe

16.01.2003


The hormone leptin, primarily produced in fat cells, helps regulate food intake, metabolism and reproduction. It has also been shown to promote and sustain the bodys immune response by binding to T lymphocytes - the frontline cells that protect against infection.



The disease experimental autoimmune encephalomyelitis (EAE) in mice is currently used by researchers as a model of human multiple sclerosis (MS). The disease is characterized by the production of autoreactive T lymphocytes that turn against the body and attack cells within the brain and spinal cord, first inducing weight loss and ultimately resulting in paralysis.

In the January 15 issue of the Journal of Clinical Investigation, Giuseppe Matarese and colleagues at IEOS-CNR at Università di Napoli "Federico II", Napoli, Italy report that just prior to developing the clinical symptoms of EAE, mice experience a significant burst of leptin which correlates with a reduction in food intake and weight loss. Furthermore, subjecting mice to acute starvation, which prevents the production of leptin, was found to delay the onset and reduce the severity of disease. In addition, leptin secretion from T lymphocytes was found to further contribute to overall leptin production during EAE.


"Once again we witness the remarkable choreography of molecules related to body weight and energy metabolism and the parallel roles of these same molecules in the finely tuned immune response" stated Dr. Lawrence Steinman and colleagues at Stanford University, California in their accompanying commentary. They go on to say that "these results imply that in autoimmunity, stress may be beneficial, and that short-term starvation may help reverse disease". Stress is detrimental and eating is recommended when fighting bacterial infections, however it appears that in the case of autoimmunity, the opposite holds true - stress and fasting is helpful.

These results suggest that leptin actively contributes to the pathogenesis of EAE, influencing both its onset and clinical severity. Interestingly, leptin is produced at much higher levels in females than males, which may account for the higher susceptibility of females to autoimmune diseases, a fact that has long puzzled scientists. The authors suggest that modulating leptin concentration through dietary approaches, and/or the administration of drugs that interfere with the bodys own production of leptin, may have potential utility in the treatment of MS and other autoimmune diseases.


###
CONTACT:
Giuseppe Matarese
Gruppo di ImmunoEndocrinologia
Instituto di Endocrinologia e Oncologia Sperimentale
Consiglio Nazionale delle Richerche (IEOS-CNR) and Cattedra di Immunologia
Dipartmento di Biologia e Patologia Cellulare e Molecolare
Università di Napoli "Federico II", via S. Pansini 5 - 80131
Napoli
ITALY
Phone: +39-081-7463311
Fax: +39-081-7463252
E-mail: gmatarese@napoli.com

View the PDF of this article at: https://www.the-jci.org/press/16721.pdf

ACCOMPANYING COMMENTARY:
The intricate interplay among body weight, stress, and the immune response to friend or foe

CONTACT:
Lawrence Steinman
Interdepartmental Program in Immunology and the
Department of Neurological Sciences Stanford University
B002 Beckman Center for Molecular medicine
Stanford, CA 94205
USA
Phone: (650) 725-6401
Fax: (650) 725-0627
E-mail: steinman@standford.edu

View the PDF of this commentary at: https://www.the-jci.org/press/17622.pdf


Brooke Grindlinger, PhD | EurekAlert!
Further information:
http://www.the-jci.org/press/16721.pdf
http://www.the-jci.org/press/17622.pdf

More articles from Health and Medicine:

nachricht Indications of Psychosis Appear in Cortical Folding
26.04.2018 | Universität Basel

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

European particle-accelerator community publishes the first industry compendium

26.04.2018 | Physics and Astronomy

Multifunctional bacterial microswimmer able to deliver cargo and destroy itself

26.04.2018 | Life Sciences

Why we need erasable MRI scans

26.04.2018 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>