The incidence of gastrointestinal stromal tumours (GISTs), generally considered a rare sarcoma, is more than three times as high as previously believed, according to data presented in Nice at the 27th annual European Society of Medical Oncology (ESMO) Congress. An accurate estimate of GIST incidence has been elusive because of diagnostic ambiguities, now largely resolved by modern immunohistochemistry.
The higher incidence of GIST – calculated at 16 per 1,000,000 people annually – is especially significant because there is now an effective treatment for GIST, the oral therapy imatinib, formerly known as STI 571. The availability of an effective therapy makes it vital to accurately diagnose the disease.
The study, the first population-based examination of the incidence of GIST, was presented by a team headed by Lars-Gunnar Kindblom, MD, PhD, of Sahlgrenska Academy at Göteborg University, Sweden. The team analyzed the medical records and tissue blocks of patients seen from 1983 to 2000 and found 400 cases of true GIST. This was more than three times as many as originally diagnosed. The reanalysis relied in large part on CD 117 (Kit) immunohistochemistry, which Dr. Kindblom pioneered over the past three years. He recommended wider use of CD 117 (Kit) staining for gastrointestinal tumours. Kit receptors in these tumours are the telltale signs of GIST.
Carina Elmäng | alfa
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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