New breast cancer gene discovered
DBC2 gene missing or inactive in 60% of breast cancers examined
Scientists at Cold Spring Harbor Laboratory and the University of Washington have discovered a new tumor suppressor gene that is missing or inactive in as many as 60% of breast cancers, and is also altered in lung cancer.
The discovery of the gene, called DBC2 (for deleted in breast cancer) is highly significant because DBC2 is among the first tumor suppressor genes to be clearly associated with sporadic breast cancer. Sporadic disease accounts for greater than 90% of all forms of breast and other cancers, in contrast to heritable forms of cancer, which account for a relatively small percentage of the disease.
Importantly, the researchers showed that production of the Dbc2 protein in breast cancer cells kills the cancer cells or stops them from growing.
The study - to be published on October 15 in the Proceedings of the National Academy of Sciences - will be published on-line (at PNAS Early Edition, http://www.pnas.org/papbyrecent.shtml) during the week of October 7. The media embargo will lift at 5:00 PM EST on Monday, October 7.
In 1997, the same research group at Cold Spring Harbor Laboratory, led by Dr. Michael Wigler, identified one of the only other tumor suppressor genes (called PTEN) to be clearly associated with sporadic cancer. In 1981, Dr. Wiglers group discovered the first cancer-causing oncogene, called RAS, from human cells.
In 1990, the same research group at the University of Washington, led by Dr. Mary-Claire King, discovered the first gene linked to hereditary breast cancer, called BRCA1.
For more information, a comprehensive press release, a copy of the study, or to arrange interviews with Dr. Wigler or Dr. King, please contact Peter Sherwood, Chief Science Correspondent, Cold Spring Harbor Laboratory (tel: 516-367-6947; e-mail: firstname.lastname@example.org
Peter Sherwood | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Researchers from Göttingen University discover additional function of opsins
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
Researchers embark on aerial campaign over Northeast Greenland
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
Data collected on ocean-ice interactions in the little-researched regions of the far south
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...