Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetic findings in monkey herpes virus could aid research in human cancer

01.10.2002


For the first time, scientists at the University of North Carolina at Chapel Hill have discovered similar gene activity profiles between a herpes virus that affects rhesus macaque monkeys and a human herpes virus linked to Kaposi’s sarcoma. This cancer is endemic among Mediterranean and sub-Sahara African populations. In the last 20 years, however, the disease has occurred most frequently in people with AIDS.



The study team, led by Dr. Blossom Damania, assistant professor of microbiology and immunology at UNC School of Medicine and a member of the Lineberger Comprehensive Cancer Center, also has identified three new genes in the rhesus monkey rhadinovirus that show high structural similarity to those in human herpesvirus-8, also known as Kaposi’s sarcoma-associated herpesvirus, or KSHV.

The new research, which appears in the Journal of Virology on Tuesday (Oct 1), lays the foundation for future studies using recombinant rhesus viruses that could eventually form the basis of targeted drug therapies against specific KSHV genes.


Researchers in microbial genetics use recombinant technology to study the effect of altered genes on the life cycle of viruses linked to human disease. These studies require large quantities of virus grown in tissue culture, which is a problem with the human virus, KSHV, because it cannot be cultured efficiently.

Damania said the simian virus can grow to very high titers in tissue culture and then grown in large quantities. These can be used in making recombinant viruses for testing in a rhesus macaque model.

"By developing this model, we can determine the genes that are important for virus survival, viral growth and replication, and genes that enable the virus to induce malignancies in its host. Once you’ve established the genes that are required to do all of these things, you can start thinking about developing drug therapies against these genes to prevent virus spread and to prevent the virus from inducing cancer in its host. So there is potential for developing at least two drug therapies at this point in time."

The scientific literature suggests that less than 10 percent of people in the Western Hemisphere are infected with KSHV; however, these percentages are currently under investigation. But around the Mediterranean, particularly Italy, Spain, Egypt and Greece, the percentage is between 25 percent and 40 percent.

And then there is sub-Saharan Africa, where the infected population is greater than 50 percent, Damania said. "The problem is very bad because of the HIV epidemic," Damania added. "It’s known that immune suppression is a factor. Whether you’re HIV-infected or a transplant patient taking immunosuppressive drugs or a patient undergoing chemotherapy, you are more likely to develop Kaposi’s sarcoma. In sub-Saharan Africa, many children 6 years of age develop Kaposi’s with very bad lesions. It’s the number one childhood cancer in this region primarily as a result of widespread HIV infection in the area."

KSHV is also associated with B-cell lymphomas, a type of blood cancer. "Although Kaposi’s sarcoma is the most common cancer linked to KSHV, many individuals frequently develop B-cell lymphomas, as well," Damania said.

"At the present time, most herpes viruses cannot be cured but their outbreak can be prevented. And so the best we can hope for at this point in time is an effective preventive strategy rather than a cure. Our research will help move us toward identifying potentially better therapies."

Leslie Lang | EurekAlert!

More articles from Health and Medicine:

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

nachricht Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>