Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rutgers research shows caffeine may prevent skin cancer

27.08.2002


Treating the skin with caffeine has been shown to prevent skin cancer in laboratory studies conducted in the Susan Lehman Cullman Laboratory for Cancer Research at Rutgers, The State University of New Jersey.



"It is not a sun-screening effect, but it’s something more than that – it’s a biological effect," said Allan Conney, William M. and Myrle W. Garbe Professor of Cancer and Leukemia Research at Rutgers’ Ernest Mario School of Pharmacy. "We may have found a safe and effective way of preventing skin cancer," he said of the discovery, described in the Proceedings of the National Academy of Sciences early online edition, available the week of Aug. 26.

It has been known for a long time that skin cancer is caused predominantly by sunlight. The authors, a group that included Conney and a team of other researchers in the laboratory, explained that sunscreen use has decreased the risk of skin cancers, but there is a need to identify additional approaches for skin-cancer prevention in individuals previously exposed to high-dose levels of sunlight.


The research team, all members of the school’s department of chemical biology, studied a special strain of hairless mice that had been exposed to ultraviolet B light twice weekly for 20 weeks. This put the mice at risk for tumor formation and skin cancer. After stopping the exposures, the researchers applied caffeine and epigallocatechin gallate (EGCG), two components of green tea, topically to the skin. Both caffeine and EGCG significantly inhibited cancer formation in the mice.

Although the study showed that most of the positive effects were true for both of these substances, caffeine has the advantage over EGCG. EGCG is chemically less stable, so there could be a problem in applying it topically, Conney said A previous study conducted in the laboratory dealt with caffeine taken orally. The caffeine was provided in the drinking fluid for the mice and the researchers found it inhibited ultraviolet light-induced tumors and cancers in this case, as well. Conney cites advantages to using the direct skin application over oral administration, pointing to the ability to provide more highly concentrated doses and larger overall dosages. "Whether you can give enough orally to be effective in humans is not known," said Conney. "Whether people could ingest that amount without becoming hyperactive is also a real question mark."

The newly published study also reported the highly selective action of both caffeine and EGCG in killing cancer cells. Adjacent normal skin cells were not affected. "The discovery of this selectivity was very exciting to us," said Conney. "Also, in our study it didn’t matter if the tumors were benign or malignant; cells in both were killed while leaving the normal cells alone."

The study suggests further research is needed to determine whether or not the skin application of these agents would be effective in people. The researchers anticipate human clinical trials in the near future. "For now," said Conney, "if you are a mouse, it would be terrific. In people we just don’t know yet."

Joseph Blumberg | EurekAlert!
Further information:
http://www.rutgers.edu/

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>