Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cell transplants look promising for stroke recovery

27.08.2002


Using transplants of bone marrow cells improved the recovery from stroke in rat experiments, according to a study published in the August 27 issue of Neurology, the scientific journal of the American Academy of Neurology.



The rats treated with an intravenous transplant of adult human stromal cells (mature cells from bone marrow) had significant improvements in their ability to function 14 days after the stroke, compared to rats that did not receive transplants after a stroke.

"These are smart cells that selectively migrate to the site of injury and become little factories producing an array of helpful molecules to repair the tissue," said study author Michael Chopp, PhD, of Henry Ford Hospital in Detroit, Mich., and Oakland University in Rochester, Mich. "We believe this therapy shows promise in treating stroke, Parkinson’s disease, spinal cord injury and traumatic brain injury."


For the study, bone marrow cells were taken from three healthy human donors. Strokes were then induced in the rats and they were given the cells intravenously one day after the stroke. Other groups treated with fibroblast cells or not treated served as controls.

The rats were tested on their motor and sensory abilities and on their reflexes before the stroke and at one day, seven days and 14 days after the stroke. In a test of sensory abilities 14 days after the stroke, the rats treated with marrow stromal cells completed the test 60 percent faster than the non-treated rats. A detailed neurological examination showed that 14 days after the stroke the treated rats had a 30-percent improvement in overall neurological score compared to the control rats.

Compared to the control rats, the rats receiving marrow stromal cells produced more neurotrophic factors and nerve growth factors that stimulate cells to grow. They also had less cell death in the area of the stroke than the control rats. Chopp said the next step is to test the procedure in small numbers of humans to make sure it is safe. Marrow stromal cells have been used in human cancer patients.

The treatment is exciting in part because it appears to give doctors a longer time window to treat stroke patients than current treatments, according to neurologist and stroke recovery researcher Thomas A. Kent, MD, of the University of Texas Medical Branch in Galveston, Texas, who wrote an editorial accompanying the article.

"It’s very difficult to treat people with a stroke within a narrow time window," he said. "Many people still don’t recognize the symptoms of stroke and get to an emergency room quickly enough for treatment. If this new treatment is effective, it could expand the treatment window by several hours or even longer."

Kent cautioned, however, that more studies are needed to determine the long-term effects of the transplants.

Cheryl Alementi | EurekAlert!

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>