Water-filtered infrared-A (wIRA) irradiation has already been shown to enhance penetration of clinically used topically applied substances in humans through investigation of functional effects of penetrated substances like vasoconstriction by cortisone.A study of the Charité Berlin, just published on July 21st, 2008, in the interdisciplinary medical e-Journal "GMS German Medical Science" of the Association of the Scientific Medical Societies in Germany (AWMF) , investigated the influence of wIRA irradiation on the dermatopharmacokinetics of topically applied substances by use of optical methods, especially to localize penetrating substances, in a prospective randomised controlled study in humans.
In mode B, the skin surface was irradiated with wIRA over 30 min before application of the two dyes (water-filtered spectrum: 590-1400 nm with dominant amount of wIRA). In mode C, the two dyes were applied and immediately afterwards the skin was irradiated with wIRA over 30 min. In all modes, tape stripping started 30 min after application of the formulations. Main variable of interest was the ratio of the amount of the dye in the deeper (second) 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum.
The penetration profiles of the hydrophilic fluorescein showed in case of pretreatment or treatment with wIRA (modes B and C) an increased penetration depth compared to the non-irradiated skin (mode A): The ratio of the amount of the dye in the deeper (second) 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum showed medians for mode A of 0.017, for mode B of 0.084, for mode C of 0.104 (significant difference between modes).In contrast to fluorescein, the lipophilic curcumin showed no differences in the penetration kinetics, in reference to whether the skin was irradiated with wIRA or not. These effects were confirmed by laser scanning microscopy. Water-filtered infrared-A irradiation increased the hydration of the stratum corneum: transepidermal water loss rose from approximately 8.8 g m-2 h-1 before wIRA irradiation to 14.2 g m-2 h-1 after wIRA irradiation and skin hydration rose from 67 to 87 relative units. Skin surface temperature increased from 32.8°C before wIRA to 36.4°C after wIRA irradiation.
As most topically applied substances for the treatment of patients are mainly hydrophilic, wIRA can be used to improve the penetration of substances before or after application of substances, in the first case even of thermolabile substances. wIRA therefore has broad clinical relevance as a contact free alternative to an occlusive dressing, e.g. to improve the penetration and effect of topically applied cortisone in psoriasis or neurodermitis, of acyclovir in herpes zoster or herpes labialis, or of an acne therapeutic in acne papulopustulosa.
Water-filtered infrared-A (wIRA) as a special form of heat radiation (within 780-1400 nm) mainly consists of radiation with good penetration properties into tissue and therefore allows - compared to unfiltered heat radiation - a multiple energy transfer into tissue without irritating the skin, similar to the sun's heat radiation in moderate climatic zones. wIRA increases temperature, oxygen partial pressure, and perfusion in the tissue. In addition wIRA has non-thermal and non-thermic effects, which are based on putting direct stimuli on cells and cellular structures. wIRA can considerably alleviate pain and diminish elevated exudation and inflammation. wIRA can also show positive immunomodulatory effects.Extended clinical observation over months and years shows that skin, which is irradiated daily with wIRA, presents an improved appearance with good skin turgor and no signs of desiccation.
Wolfgang Müller | idw
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy