Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aiming to Improve Schizophrenia Treatment Through the NIMH CNTRICS Initiative

15.07.2008
Reports from the First CNTRICS Meeting

Biological Psychiatry is particularly proud to announce the publication of an issue dedicated to the product of the National Institute of Mental Health (NIMH) Cognitive Neuroscience Approaches to the Treatment of Impaired Cognition in Schizophrenia, or CNTRICS, initiative.

This July 1, 2008 issue includes eight articles on CNTRICS: one commentary, one overview paper of the CNTRICS meeting, and six review papers on the ideas developed at the first of the three scheduled CNTRICS meetings.

John H. Krystal, M.D., Editor of Biological Psychiatry and one of the authors on the overview paper, highlights the importance of this venture: “Schizophrenia is a disabling illness despite the emergence of a second generation of antipsychotic treatments. To develop better medications, we first need a better understanding of the brain and how it goes awry in schizophrenia.” He explains that the CNTRICS initiative aims “to better define the cognitive processes and the neural circuits that carry out these processes that will be the focus for schizophrenia research now and in the future.”

Thomas R. Insel, M.D., Director of the NIMH and co-author of the commentary, adds: "Cognitive neuroscience has made enormous strides in the past two decades by mapping the brain's rules and routes for information processing. CNTRICS endeavors to translate the tools and insights from cognitive neuroscience into better treatments for schizophrenia."

In the overview paper, the authors describe the background, organization and results of the meeting, which brought together academic and industry experts from basic and clinical cognitive neuroscience and drug development. Cameron Carter, M.D., Deputy Editor of Biological Psychiatry and lead author of the overview paper adds that, “In embracing basic cognitive and affective neuroscience as a translational bridge linking cellular and molecular neuroscience with clinical symptoms, and by bringing together basic and clinical scientists with those focused on treatment development, the CNTRICS process […] presents us with a new paradigm for how we go about treatment development in psychiatry.”

he experts sought to develop a consensus building process on which aspects of impaired cognition in schizophrenia should be targeted for new treatment development. The perspectives of the experts, results of discussions and recommendations for cognitive treatment targets are summarized in the six related review papers that comprise the major products of this first CNTRICS meeting.

One of the review papers, by Kevin Ochsner, Ph.D., focuses on the deficits in social and emotional functioning that are hallmarks of schizophrenia. As Dr. Ochsner explains, “The emerging disciplines of social cognitive and affective neuroscience offer new methods to study these abilities and their breakdown in schizophrenia. This paper synthesizes recent advances in these disciplines and proposes a framework for understanding the neural organization of five key social and emotional abilities.” Dr. Carter notes that “by bringing a modern social cognitive neuroscience perspective to this aspect of schizophrenia and outlining a novel and informative model of human social and emotional processing, Ochsner has provided the field an opportunity for a fresh start as well as a powerful set of tools to inform future research and treatment development.”

Charan Ranganath and colleagues, in another of the review papers, focused on addressing episodic memory impairment, which limits the daily function of individuals with schizophrenia, and is an important target for treatment development. Specifically, the CNTRICS panel nominated item-specific and relational memory tasks for immediate translational development and this paper summarizes the significant progress that cognitive neuroscience has made in understanding the cognitive and neural underpinnings of these processes. Dr. Carter comments that “Ranganath et al. provide the reader with a state of the art systems view of human memory and use this as a context for how we might advance our understanding of disabling memory deficits in schizophrenia and the abnormal brain functioning underlying them.”

The authors of the Carter et al. paper comment, “As the CNTRICS process unfolds, we hope to bring the full force of the new knowledge and technology that is cognitive neuroscience to bear on the effort to develop effective therapies for impaired cognition in schizophrenia.” Biological Psychiatry is pleased to be the home for the presentation of this work, as the field of psychiatry looks to the ideas that develop out of CNTRICS to further inform and improve schizophrenia treatment.

Jayne Dawkins | alfa
Further information:
http://www.elsevier.com

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>