Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New treatment for skeletal metastases

01.07.2002


Norwegian and Swedish researchers have developed a new type of internal radiation therapy for cancer that has spread to skeletal tissue. Experience from an early patient test is optimistic, according to a report being presented at the 18th International Cancer Congress in Oslo this week.



Many patients with advanced breast, prostate or lung cancer experience metastasis to skeletal tissue. This is often a source of pain and suffering.

Exterior irradiation and medication, including radioactive substances injected into the bloodstream, can retard cancer growth in skeletal tissue, but now a new radium isotope may offer a new and better alternative. The first tests on Norwegian and Swedish patients are currently in progress, and the experience thus far gives grounds for optimism.


Isotopes are incorporated into skeletal tissue
Special cells called osteoclasts help build up skeletal tissue and try to help repair damaged tissue in areas affected by cancer. When small doses of the element radium are injected into the bloodstream, the osteoclasts will incorporate radium instead of calcium. This means radium can be incorporated into skeletal tissue, where it will give off radiation that kills cancer cells.

"Today, this type of ’internal’ radiation therapy is usually based on pharmaceuticals that contain strontium. Strontium has a scope of six to seven millimetres, meaning it can damage bone marrow and impair the production of new blood cells. But radium223 has a scope of just two millimetres. This leads us to believe that bone marrow will incur less damage", states Senior Medical Officer Lise Balteskard, PhD, University Hospital of Northern Norway. Along with physicians at the Norwegian Cancer Hospital, she has treated the first Norwegian patients with radium223.

The element radium is found in many isotope variants with different half-lives and scopes. The new isotope is a radium223 isotope developed at the Studsvik reactor in Sweden. In addition to the short scope of the radiation, it has a half-life of only 11 days.

Pain relief

In animal trials, this new isotope had good results on breast cancer that had spread to skeletal tissue. The animals lived longer and some were cured. (Cancer Research, June 2002). Experience from the first study on 20 Norwegian and Swedish patients indicates that many were able to use a lower dose of painkillers. This indicates that the treatment is effective.

"This is a phase 1 study where we are testing different doses to determine which dose we can administer without too many side effects. First and foremost, we are examining blood platelets and white cells in the blood to see whether their production is affected. The patients have advanced cancer. It was promising that many of them could take a lower dose of painkillers, as it implies improved quality of life. However, a phase 2 study is required to perform imaging, determine whether there is any reduction in malignant tissue, and systematically examine pain relief and survival", explains Balteskard.

"Is it possible that this new radium isotope might offer a cure for skeletal metastasis?"

"We believe this treatment might be administered the first time a tumour spreads to skeletal tissue, and that it might inhibit metastases. This would have an effect on pain and quality of life and could increase survival. It is still too early to tell whether such treatment might offer a cure if administered early enough", adds Balteskard.

Abstract P 459 in Poster Session 1 refers to the Norwegian-Swedish study on radium 223.
For more information, see the abstract from the symposium: Skeletal metastases, Monday, 08.45, inter alia in 15, Serafini, which will give an overview of bone-seeking radioactive isotopes for use in cancer treatment

Hanna Hånes | EurekAlert!
Further information:
http://www.kreft.no/

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

Method uses DNA, nanoparticles and lithography to make optically active structures

19.01.2018 | Materials Sciences

More genes are active in high-performance maize

19.01.2018 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>