Norwegian and Swedish researchers have developed a new type of internal radiation therapy for cancer that has spread to skeletal tissue. Experience from an early patient test is optimistic, according to a report being presented at the 18th International Cancer Congress in Oslo this week.
Many patients with advanced breast, prostate or lung cancer experience metastasis to skeletal tissue. This is often a source of pain and suffering.
Exterior irradiation and medication, including radioactive substances injected into the bloodstream, can retard cancer growth in skeletal tissue, but now a new radium isotope may offer a new and better alternative. The first tests on Norwegian and Swedish patients are currently in progress, and the experience thus far gives grounds for optimism.
In animal trials, this new isotope had good results on breast cancer that had spread to skeletal tissue. The animals lived longer and some were cured. (Cancer Research, June 2002). Experience from the first study on 20 Norwegian and Swedish patients indicates that many were able to use a lower dose of painkillers. This indicates that the treatment is effective.
"This is a phase 1 study where we are testing different doses to determine which dose we can administer without too many side effects. First and foremost, we are examining blood platelets and white cells in the blood to see whether their production is affected. The patients have advanced cancer. It was promising that many of them could take a lower dose of painkillers, as it implies improved quality of life. However, a phase 2 study is required to perform imaging, determine whether there is any reduction in malignant tissue, and systematically examine pain relief and survival", explains Balteskard.
"Is it possible that this new radium isotope might offer a cure for skeletal metastasis?"
"We believe this treatment might be administered the first time a tumour spreads to skeletal tissue, and that it might inhibit metastases. This would have an effect on pain and quality of life and could increase survival. It is still too early to tell whether such treatment might offer a cure if administered early enough", adds Balteskard.
Abstract P 459 in Poster Session 1 refers to the Norwegian-Swedish study on radium 223.
For more information, see the abstract from the symposium: Skeletal metastases, Monday, 08.45, inter alia in 15, Serafini, which will give an overview of bone-seeking radioactive isotopes for use in cancer treatment
Hanna Hånes | EurekAlert!
Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena
Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences