Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cranberry may offer protection against antibiotic-resistant bacteria that cause UTIs

19.06.2002


Fewer Infections may mean less antibiotic therapy



Public health officials concerned about the rising problem of antibiotic resistance ¾ the immunity that bacteria develop to common prescriptions ¾ may have an ally in a common household beverage. Findings published in a research letter to the editor in the June 19, 2002 issue of The Journal of the American Medical Association (JAMA) indicate scientists have discovered that regular consumption of cranberry juice cocktail may offer protection against certain antibiotic resistant bacteria that cause urinary tract infections (UTIs).

This latest research, conducted jointly between Rutgers, The State University of New Jersey and the University of Michigan, suggests that regular consumption of cranberry juice cocktail could reduce the potential for development of UTIs, thus decreasing the need for antibiotics. In this study, scientists tested the effectiveness of cranberry juice cocktail in disabling a number of Escherichia coli (E. coli) bacteria, some of which are resistant to certain drugs. Preventing UTIs could potentially reduce the use of antibiotics, and subsequently reduce further development of antibiotic resistance.


"We found that when subjects consumed cranberry juice cocktail, their urine was capable of preventing not only susceptible, but antibiotic-resistant bacteria from attaching to the urinary tract," said Amy B. Howell, Ph.D., research scientist at Rutgers, and lead investigator of the study. "Cranberry acts to promote flushing of these problematic bacteria from the bladder into the urine stream, which should result in a lower rate of infection."

According to Betsy Foxman, Ph.D., Professor of Epidemiology and Director at the Center for Molecular and Clinical Epidemiology at the University of Michigan School of Public Health, who co-authored this study, "In light of the increasing antibiotic resistance of many bacteria, the public health significance of the role of foods, such as cranberry juice cocktail, in preventing infections warrants further consideration. A lower number of infections means reduced use of antibiotics and lower potential risk of developing further bacterial antibiotic resistance." She continued, "Additional work that I co-authored, cited in the October 4, 2001 edition of The New England Journal of Medicine, suggests that an increasing number of new E. coli strains are resistant to the most common antibiotics used to treat UTIs, prompting physicians and researchers to look for alternatives."

The JAMA findings indicate that cranberry’s well-documented anti-adhesion mechanism is effective against both the antibiotic-resistant and sensitive E. coli strains tested. Specifically, the researchers examined various E. coli isolates from the urine of women and men with UTIs. These isolates were introduced into urine samples collected from healthy subjects before and after drinking eight ounces of cranberry juice cocktail. The samples taken after the cranberry juice cocktail was consumed prevented 79 percent of antibiotic resistant bacteria from sticking to the urinary tract cells, while urine samples taken before cranberry juice cocktail was consumed failed to prevent adhesion. In total, the cranberry juice cocktail prevented 80 percent of all bacteria tested from sticking.

This study is also the first to look at duration of effect of cranberry in the urinary tract. Said Dr. Howell, "This research found that cranberry juice cocktail’s beneficial effect may start within two hours and can last for up to 10 hours in the urine, which suggests that consuming a serving in the morning and one in the evening may provide more effective anti-adhesion protection than consuming one serving a day."

A common misconception is that cranberries help maintain urinary tract health by acidifying the urine, but research supports that the anti-adhesion, or anti-stick, property of the cranberry is the key to its urinary tract health benefit. Scientists believe that the proanthocyanidins, or condensed tannins, in cranberries prevent certain E. coli bacteria from sticking to the urinary tract and causing infection.

The National Center of Complementary and Alternative Medicine, a branch of the National Institutes of Health, recently approved funding to support further research on the role of cranberry, with one area of emphasis being the effect of cranberry in prevention of UTI, and as an adjunct to antibiotics in the treatment of UTI. Funding for antimicrobial resistance research has increased more than 75 percent, from $7.8 million in 1992 to approximately $13.8 million in 1998, indicating that national concern over resistant bacteria has increased dramatically.

Cranberry juice cocktail is a food, not a drug, nor should it be used in place of a drug. Anyone who suspects an infection should always consult a physician. Cranberry juice cocktail should not be used as a treatment for infection, but may be an effective part of a prevention routine.


This study was funded by Ocean Spray Cranberries, Inc.


Michele Hujber | EurekAlert!

More articles from Health and Medicine:

nachricht UNC Team uses cellular bubbles to deliver Parkinson's meds directly to brain
05.05.2015 | University of North Carolina at Chapel Hill

nachricht Receptor provides a surprise
04.05.2015 | Julius-Maximilians-Universität Würzburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The random raman laser: A new light source for the microcosmos

Texas A&M University researchers demonstrate how a narrow-band strobe light source for speckle-free imaging has the potential to reveal microscopic forms of life

In modern microscope imaging techniques, lasers are used as light sources because they can deliver fast pulsed and extremely high-intensity radiation to a...

Im Focus: Pulsar with widest orbit ever detected

Discovered by high school research team

A team of highly determined high school students discovered a never-before-seen pulsar by painstakingly analyzing data from the National Science Foundation's...

Im Focus: Erosion, landslides and monsoon across the Himalaya

Scientists from Nepal, Switzerland and Germany was now able to show how erosion processes caused by the monsoon are mirrored in the sediment load of a river crossing the Himalaya.

In these days, it was again tragically demonstrated that the Himalayas are one of the most active geodynamic regions of the world. Landslides belong to the...

Im Focus: Through the galaxy by taxi - The Dream Chaser Space Utility Vehicle

A world-class prime systems integrator and electronic systems provider known for its rapid, innovative, and agile technology solutions, Sierra Nevada Corporation (SNC) is currently developing a new space transportation system called the Dream Chaser.

The ultimate aim is to construct a multi-mission-capable space utility vehicle, while accelerating the overall development process for this critical capability...

Im Focus: High-tech textiles – more than just clothes

Today, textiles are used for more than just clothes or bags – they are high tech materials for high-tech applications. High-tech textiles must fulfill a number of functions and meet many requirements. That is why the Fraunhofer Institute for Silicate Research ISC dedicated some major developing work to this most intriguing research area. The result can now be seen at Techtextil trade show in Frankfurt from 4 to 7 May. On display will be novel textile-integrated sensors, a unique multifunctional coating system for textiles and fibers, and textile processing of glass, carbon, and ceramics fibers to fiber preforms.

Thin materials and new kinds of sensors now make it possible to integrate silicone elastomer sensors in textiles. They are suitable for applications in medical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Green Summit 2015: the summit of the essential

05.05.2015 | Event News

HHL Energy Conference on May 11/12, 2015: Students Discuss about Decentralized Energy

23.04.2015 | Event News

“Developing our cities, preserving our planet”: Nobel Laureates gather for the first time in Asia

23.04.2015 | Event News

 
Latest News

3-D models of neuronal networks reveal organizational principles of sensory cortex

06.05.2015 | Life Sciences

Molecular link found between high glucose, metabolic disease

06.05.2015 | Life Sciences

Services for innovative urban systems

06.05.2015 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>