Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Food “superallergies”: the first Italian study proves that they can be cured with the incriminated allergen

10.03.2008
By setting an alimentary desensitization protocol against milk and egg proteins, the medical team of the Pediatric Clinic of the University of Trieste, located at the Institute of Child Health Burlo Garofolo, has demonstrated the possibility to reeducate the organism of “superallergic” children to accept incriminated foods without suffering from severe, and occasionally lethal reactions such as anaphylaxis or edema of the glottidis.

The study – directed by professor Alessandro Ventura, Director of the Clinic – lasted three years, at the end of which 36% of the children involved, once severely allergic with important, generalized reactions to even minimal contact with the dangerous food, and therefore life threatened, has re-achieved the ability to follow a normal diet without presenting any adverse reactions. On the other hand, 54% of the patients involved in the study were able to tolerate minimal quantities of the incriminated food in their diet.

With this experimental work, recently published by the Journal of Allergy and Clinical Immunology, the researchers confirmed the validity of a face-to-face direct approach to severe food allergies that the Burlo Garofolo has been persecuting since long, in countertrend to the majority of the allegologists that limit the treatment of severe food allergies to strict elimination of the harmful food from the diet. In Europe, allergies to specific foods such as milk or egg proteins are on the up. In Italy, at least 400,000 children aged 5 - 15 suffer from this disorder, and 3000 are at risk of severe reactions for minimal contact with the allergen.

The protocol – Sixty Italian children, classified as “superallergic” to milk or eggs according to the severity of the symptoms, were selected and involved in the study. “The desensitization schedule is articulated in two parts – explains Giorgio Longo, Director of the Allergology Department of the Burlo Garofolo – the first one, where there is a major risk of severe reactions, lasts 10 days and takes place in the Hospital. During the hospitalization, milk is administered at rapidly increasing doses, at two hours intervals, until at discharge the child is able to intake 10 to 20 ml of pure milk”. The second part takes place at home, with the cooperation of the parents that, according to a scheme provided by the doctors continue the administration of milk, once a day, at a much slower and gradual rate of increase. In doing so the child is able to tolerate ever increasing doses of milk, until he or she is able to follow a completely normal diet. The positive result (recovery) is usually obtained within a year.

The results – One third of the treated patients now eats freely, whatever he or she feels like. Half of them have not reached a normal diet yet, but are able to introduce significant quantities of milk without showing any adverse reaction. 10% of the treated patients did not respond positively to the treatment, and despite all the attempts, keep on to presenting important adverse reactions.

Are there any risks with this strategy? “We did not have any lethal cases. However, desensitization can be accompanied by some complications – confirms Egidio Barbi from the Pediatric Clinic, available 24 hours a day for emergencies that might occur during the home phase of the protocol. “However, given the potential benefits, it’s a risk worth to be taken. The protective strategy, i.e. the elimination of the incriminated food, is dangerous as well: statistically, even children who intentionally avoid the dangerous food occasionally come across the allergen during the 5 years following the onset of the diet. Usually, these patients develop very severe reactions.”

Cristina Serra | alfa
Further information:
http://www.burlo.trieste.it

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>