Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Overweight and obese men have lower PSA values, even before they get prostate cancer

21.02.2008
Men who are overweight or obese have lower concentrations of prostate-specific antigen (PSA) in their blood than their normal-weight counterparts, according to a new study led by Duke University Medical Center researchers.

The finding echoes earlier results on PSA concentrations found in obese and overweight men with prostate cancer and highlights the need to reconsider PSA threshold values for heavier patients, and to encourage those patients to get serious about losing weight.

“A study released last year from our group showed that obese and overweight men with prostate cancer had deceptively low PSA scores compared to normal-weight men with prostate cancer, but we now have extended our findings to show that this trend holds true in the general screening population,” said Marva Price, R.N., a family nurse practitioner and researcher in Duke’s School of Nursing, the Duke Comprehensive Cancer Center and the Duke Prostate Center..

“We found that mildly obese men’s PSA scores were fourteen percent lower than normal-weight men, and moderately and severely obese men had 29 percent lower PSA values,” Price said.

Doctors have proposed that overweight and obese men have lower PSA scores because their bodies have a greater volume of blood. Larger blood volumes dilute the amount of PSA in the bloodstream, making the concentration of PSA -- which is what is measured to screen for prostate cancer -- lower.

The latest results appear online in the Feb. 9, 2008 issue of the journal Urology. The study was funded by the United States Department of Defense.

PSA is considered the gold standard for detecting prostate cancer; it is a protein released into the blood by the prostate gland, and is elevated in the presence of cancer.

For this study, researchers looked at PSA scores among 535 men who took part in a free prostate cancer screening program. Seventy-three percent of the group was overweight or obese.

“The prevalence of obesity in the United States has doubled in the past 15 years,” Price said. “Our study demonstrates yet another health danger that obesity poses. One in three Americans is obese, and a man who is 5'11" and weighs 215 pounds is considered obese.

The best advice clinicians can give their patients is to adopt healthier lifestyles, said Stephen Freedland, M.D., a urologist at Duke and the study’s senior author. “We tell patients to exercise three or four times a week, eat a healthier diet, high in vegetables and fruits, and keep getting screened,” he said. However, to compensate for the lower PSA values, Freedland also recommends lowering the PSA threshold that is considered abnormal for obese men. “If we don’t do that, we may be missing cancers in obese men, which could lead to delayed diagnosis and poorer outcomes.”

Lauren Shaftel Williams | EurekAlert!
Further information:
http://www.duke.edu

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>