Children born with thyroid hormone deficiencies (hypothyreosis) are in danger of mental and locomotor underdevelopment if they remain untreated. However, scientists are unsure about what causes the damage and about how much attention should be given to the mother’s hormone levels during pregnancy. In Sweden, all newborn babies, but not all pregnant women, are tested for hypothyreosis.
Scientists at Karolinska Institutet have now shown in experiments on mice that both the mother’s and the child’s thyroid hormone are necessary for proper locomotor development. Hormone deficiencies during early pregnancy, when the mother is the only source of the hormone, produced locomotor disorders in the mice that persisted into adulthood, at which point they were beyond treatment.
“Hypothyreosis is easy to treat if it’s discovered,” says Professor Björn Vennström, who has led the study. “The results provide fresh support for those who advocate the more thorough monitoring of pregnant women.”
The scientists were also able to show that the cause of the locomotor disorders was an abnormal development of specific nerve cells in the motor cortex and cerebellum. The findings thus give new and important insights into the part played by thyroid hormone in brain development.
The study used gene modified mice with a mutation in one of the two receptors for thyroid hormone. The discoveries mean that patients with mutations of the same receptor can, for the first time, be identified and treated.Publication:
Katarina Sternudd | alfa
Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University
The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy