Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Non rejection bioreabsorbable scaffold for jaw implant, developed by Custom-Fit

10.02.2009
The EU funded project Custom-Fit has been working on a solution to the rejection issue of mandibular implants: a scaffold made using a brand new material which is bioreabsorbable, that is, once implanted, it is substituted by re-grown natural bone in 6-12 months.

The Custom-Fit project is a technological research program involving 30 partners from 12 European countries. Its goal is the development a new manufacturing paradigm for producing personalised products, customised to the individual shape of the human body.

This has been done by integrating Scanning Technologies, newly developed CAD systems (Computer Aided Design) and Rapid Manufacturing technologies, the so called ‘additive techniques, which build a object layer by layer, starting from a 3D design, adding material where needed instead of removing it where not.

The mandible implant has been chosen as one of the test benches to try out this new manufacturing technology, together with knee implants, trans-femoral prosthesis, and two consumer goods, motorbike seats and motorbike helmets, products that are well suited to be customised to meet individual body shapes.

The Custom-Fit way to manufacture a mandible implant takes advantage of the best available technologies in design, in material science and in manufacturing, thanks to the member partners of the Custom-Fit consortium.

The process is the following (Image #2). The jaw bone geometry is studied through Computerised Tomography, CT images are then worked using specialised software (Mimics by Materialise) capable of extracting the jaw bone surface in a standard file format for later surface design which uses STL (Standard Triangulation Language). This is capable of distinguishing the damaged part of the bone from the healthy one.

Then, a surface model of the implant, which has to replace the damaged bone part, is easily designed with a CAD system (3-matic, by Materialise in Belgium) that allows the direct playing with facet models (STL-files) avoiding the conversion to CAD-surfaces, which normally requires a long computer processing time; this dramatically shortens the implant design phase. Here, engineers and surgeons work in collaboration to decide were to cut the jaw and consequently the size of the scaffold.

The 3D model of the implant is then completed by adding the internal structure, i.e. adding porosity using more design software called Innerspace that was developed by the Custom-Fit partner, TNO, in the Netherlands.

Finally the model is sliced ready to be manufactured on a special Rapid Manufacturing tool, capable of printing multi-material and porous objects, using high viscosity resins, the Inkjet Printing tool also developed by TNO.

And one of the resins printable by IP is the bioreabsorbable resin developed by DSM, a Dutch company and Custom-Fit partner, that is responsible for new material development. First samples have been successfully printed (Image #3).

It will take years for the new scaffolds to be approved for implantation in human beings, but the approval procedure has now been started, with In-Vitro Cytoxicity tests.

Several advantages will be brought about by bioreabsorbable scaffolds: no rejection of the foreign material, new bone will be able to grow over time (for children), further treatment like dental implants will remain possible and definitively the implant will not be a foreign object any more, but will be completely replaced by new natural bone.

It is a revolution in implant surgery, Custom-Fit made the first step.

Sunny Martínez | alfa
Further information:
http://www.custom-fit.org

More articles from Health and Medicine:

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

nachricht Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>