Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prolactin reduces fat metabolism

02.04.2009
The hormone prolactin is necessary for the production of breast milk, but it also affects adipose (fatty) tissue and the body's metabolism. This has been shown by a thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden. Raised prolactin levels in a woman who is not pregnant or breast feeding reduces lipid (fat) metabolism.

Over 30 000 Swedish men and women may have raised levels of prolactin. Women who are pregnant or breast feeding have naturally raised levels of prolactin, but stress, some medicines and benign brain tumours can also lead to raised levels of the hormone.

In many cases doctors don't know what causes the rise in hormone levels. In women, an abnormally high level can cause menstrual disturbances and infertility, and may also result in insulin resistance.

"In recent years scientists have also recognised the role of prolactin in the development of obesity, but little research has been done into the precise mechanism by which prolactin regulates metabolism," says Louise Nilsson.

In her thesis Louise Nilsson shows that there are receptors for the breast feeding hormone in human fatty tissue.

"We have demonstrated that prolactin reduces the ability of fatty tissue to store sugar and fat, which then could accumulate in the blood and certain tissues instead. This in turn increases the risk of cardiovascular disease."

Prolactin also affects the body's ability to metabolise fat. An ongoing study suggests that the hormone impairs the body's ability to maintain a balanced metabolism.

"When fatty tissue receives signals from prolactin, it reacts by reducing the production of another hormone called adiponectin, which is important for the metabolism of a variety of nutrients," explains Louise Nilsson.

FACTS ABOUT PROLACTIN
Prolactin is a hormone produced by the pituitary gland in the brain. It stimulates the production of milk in the breast and also inhibits hormone production in the ovaries and testicles. Prolactin levels are considerably raised in pregnancy, and prolactin secretion is also stimulated by breast feeding.

The Sahlgrenska Academy is the faculty of health sciences at the University of Gothenburg, Sweden. Education and research are conducted within the fields of pharmacy, medicine, odontology and health care sciences.

About 4000 undergraduate students and 1000 postgraduate students are enrolled at Sahlgrenska Academy. The staff is about 1500 persons. 850 of them are researchers and/or teachers.

For further information please contact:
Louise Nilsson, tel: +46 (0)31 786 3533, +46 (0)70 523 67 41, e-mail: louise.nilsson@gu.se
Supervisor:
Professor Håkan Billig, tel: +46 (0)31 786 3534, e-mail: hakan.billig@fysiologi.gu.se

Doctoral thesis from the Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden.

Title of thesis: Effects of prolactin on metabolism - changes induced by hyperprolactinemia

The thesis has been defended.
Link to the thesis: http://hdl.handle.net/2077/19049
Press information: Elin Lindström Claessen
Tel: +46 (0)31 786 3837, +46 (0)70 829 43 03
e-mail: elin.lindstrom@sahlgrenska.gu.se
The thesis is based on the following papers:
I Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits
lipoprotein lipase activity in human white adipose tissue.
Ling C, Svensson L, Odén B, Weijdegård B, Edén B, Edén S, Billig H.
J Clin Endocrinol Metab. 2003 Apr;88(4):1804-8.
II Prolactin suppresses malonyl-CoA concentration in human adipose tissue.
Nilsson L, Roepstorff C, Kiens B, Billig H, Ling C.
Submitted
III Prolactin and growth hormone regulate adiponectin secretion and receptor
expression in adipose tissue.
Nilsson L, Binart N, Bohlooly-Y M, Bramnert M, Egecioglu E, Kindblom J, Kelly
PA, Kopchick JJ, Ormandy CJ, Ling C, Billig H.
Biochem Biophys Res Commun. 2005 Jun 17;331(4):1120-6.
IV Suppressed lipid oxidation in women with pathological hyperprolactinemia.
Nilsson L, Bramnert M, Wessman Y, Billig H, Ling C.
Manuscript

Helena Aaberg | idw
Further information:
http://hdl.handle.net/2077/19049
http://www.gu.se/

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>