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Plant-based diet may reduce obese children's risk of heart disease


Preliminary study by Cleveland Clinic finds plant-based vegan diet may be more effective than American Heart Association diet in reducing cardiovascular risks

Obese children who begin a low-fat, plant-based vegan diet may lower their risk of heart disease through improvements in their weight, blood pressure, body mass index, cholesterol levels, insulin sensitivity, and high-sensitivity C-reactive, according to Cleveland Clinic research published online today by The Journal of Pediatrics.

The four-week study - led by Michael Macknin, M.D., a staff pediatrician at Cleveland Clinic Children's - compared a plant-based vegan diet to the American Heart Association (AHA) diet in 28 obese children with high cholesterol between the ages of 9 and 18. One parent of each child also followed the assigned diet plan.

Those on the plant-based diet consumed plants and whole grains, with limited avocado and nuts, no added fat, and no animal products. These children experienced significant improvements in nine measures: BMI, systolic blood pressure, weight, mid-arm circumference, total cholesterol, low-density lipoprotein (LDL) cholesterol, and insulin, as well as two common markers of heart disease, myeloperoxidase and high-sensitivity C-reactive protein.

Those on the American Heart Association diet consumed fruits, vegetables, whole grains and non-whole grains, limited sodium, low-fat dairy, selected plant oils, and lean meat and fish in moderation. These children experienced significant improvements in four measures: weight, waist circumference, mid-arm circumference and myeloperoxidase.

"As the number of obese children with high cholesterol continues to grow, we need to have effective lifestyle modifications to help them reverse their risk factors for heart disease," Dr. Macknin said. "We've known that plant-based diets are beneficial in adults in preventing and possibly reversing heart disease. This study shows that the same may be true in children too, though more studies are needed.

"Cardiovascular disease begins in childhood. If we can see such significant improvements in a short four-week study, imagine the potential for improving long-term health into adulthood if a whole population of children began to eat these diets regularly."

Children on the plant-based diet reduced their consumption of animal protein from 42 grams daily to 2.24 grams daily, while also reducing their percentage of calories from fat and saturated fat to 18 percent and 3.6 percent, respectively.

Children on the AHA diet were to consume less than 30 percent of their total calories from fat, less than 7 percent of calories from saturated fat, less than 1500 mg sodium and less than 300 mg cholesterol.

"Most families in the study were able to follow these dietary guidelines for the four-week study," Dr. Macknin said, "but we found that they had difficulty purchasing the food necessary for a balanced plant-based diet. So we know that plant-based diets are effective, but if they are to be widely used, we need to make access to plant-based, no-added-fat foods easier and more affordable."

The study was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (UL1TR000439) and Research Program Committee (2012-1063 4), as well as Pediatric Research Fund Grants from Cleveland Clinic.

About Cleveland Clinic

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S.News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual "America's Best Hospitals" survey. More than 3,000 full-time salaried physicians and researchers and 11,000 nurses represent 120 medical specialties and subspecialties. The Cleveland Clinic health system includes a main campus near downtown Cleveland, eight community hospitals, more than 75 Northern Ohio outpatient locations, including 16 full-service Family Health Centers, Cleveland Clinic Florida, the Lou Ruvo Center for Brain Health in Las Vegas, Cleveland Clinic Canada, and, scheduled to begin seeing patients in 2015, Cleveland Clinic Abu Dhabi. In 2012, there were 5.1 million outpatient visits throughout the Cleveland Clinic health system and 157,000 hospital admissions. Patients came for treatment from every state and from more than 130 countries. Visit us at Follow us at

Editor's Note: Cleveland Clinic News Service is available to provide broadcast-quality interviews and B-roll upon request.


Alana D. Wyche, 216.445.9274,

Angie Kiska, 216.444.6002, 

Alana Wyche | EurekAlert!

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