Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pill some day may prevent serious foodborne illness, scientist says

10.01.2012
Modified probiotics, the beneficial bacteria touted for their role in digestive health, could one day decrease the risk of Listeria infection in people with susceptible immune systems, according to Purdue University research.

Arun Bhunia, a professor of food science; Mary Anne Amalaradjou, a Purdue postdoctoral researcher; and Ok Kyung Koo, a former Purdue doctoral student, found that the same Listeria protein that allows the bacteria to pass through intestinal cells and into bloodstreams can help block those same paths when added to a probiotic.

"Based on the research, it looks very promising that we would get a significant reduction in Listeria infections," said Bhunia, whose findings were published this month in the journal PLoS One.

Bhunia's earlier work showed that Listeria triggers intestinal cells to express heat shock protein 60 on their surfaces. That allows Listeria to bind to the intestinal cells using an adhesion protein and pass into them, acting as a sort of gateway to the bloodstream.

Once in the bloodstream, even small doses of Listeria can cause fever, muscle aches, nausea and diarrhea, as well as headaches, stiff neck, confusion, loss of balance and convulsions if it spreads to the nervous system. It can also cause abortion and stillbirth in pregnant women.

According to the U.S. Centers for Disease Control and Prevention, it sickens about 1,500 and kills 255 people each year in the United States and primarily affects pregnant women, newborns, older adults and those with weakened immune systems.

"We're seeing fewer Listeria infections, but the severity of those infections is still high," Amalaradjou said.

The researchers found that probiotics alone were ineffective in combatting Listeria, so they stole a trick from the bacteria's own playbook. By adding the Listeria adhesion protein to the probiotic Lactobacillus paracasei, they were able to decrease the number of Listeria cells that passed through intestinal cells by 46 percent, a significant decrease in the amount of the bacteria that could infect a susceptible person.

With the adhesion protein, Lactobacillus paracasei interacts with heat shock protein on the surface of intestinal cells just as Listeria would. The probiotic then attached to the intestinal cells, crowding out Listeria.

"It's creating a competition," Bhunia said. "If Listeria comes in, it doesn't find a place to attach or invade."

Bhunia said he could one day foresee the development of a pill or probiotic drink that could be given to at-risk patients to minimize the risk of Listeria infection.

The results came from tests on human intestinal cells. The next step would be animal testing. Bhunia said that would allow him to see whether different doses would have a greater effect.

Bhunia used funding from the U.S. Department of Agriculture in previous work on Listeria, but the current study was internally funded.

Writer: Brian Wallheimer, 765-496-2050, bwallhei@purdue.edu
Sources: Arun Bhunia, 765-494-5443, bhunia@purdue.edu
Mary Anne Amalaradjou, 765-494-8256, mamalara@purdue.edu
Ag Communications: (765) 494-2722;
Keith Robinson, robins89@purdue.edu
Agriculture News Page

Brian Wallheimer | EurekAlert!
Further information:
http://www.purdue.edu

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>