Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Pesticide levels in blood linked to Parkinson's disease

People with Parkinson’s disease have significantly higher blood levels of a particular pesticide than healthy people or those with Alzheimer’s disease, researchers at UT Southwestern Medical Center have found.

In a study appearing in the July issue of Archives of Neurology, researchers found the pesticide beta-HCH (hexachlorocyclohexane) in 76 percent of people with Parkinson’s, compared with 40 percent of healthy controls and 30 percent of those with Alzheimer’s.

The finding might provide the basis for a beta-HCH blood test to identify individuals at risk for developing Parkinson’s disease. The results also point the way to more research on environmental causes of Parkinson’s.

“There’s been a link between pesticide use and Parkinson’s disease for a long time, but never a specific pesticide,” said Dr. Dwight German, professor of psychiatry at UT Southwestern and a senior author of the paper. “This is particularly important because the disease is not diagnosed until after significant nerve damage has occurred. A test for this risk factor might allow for early detection and protective treatment.”

About 1 million people in the U.S. have Parkinson’s, a number expected to rise as the population ages. The disease occurs when brain cells in particular regions die, causing tremors, cognitive problems and a host of other symptoms.

The study involved 113 participants, ages 50 to 89. Fifty had Parkinson’s, 43 were healthy and 20 had Alzheimer’s. The researchers tested the subjects’ blood for 15 pesticides known as organochlorines.

These pesticides, which include the well-known DDT (dichlorodiphenyltrichloroethane), were widely used in the U.S. from the 1950s to the 1970s but are more tightly regulated now. They persist in the environment for years without breaking down. In the body, they dissolve in fats and are known to attack the type of brain nerves that die in Parkinson’s disease, the researchers said.

“Much higher levels of the beta-HCH were in the air, water and food chain when the Parkinson’s patients were in their 20s and 30s,” Dr. German said. “Also, the half-life of the pesticide is seven to eight years, so it stays in the body for a long time.”

Parkinson’s disease is more common among rural men than other demographic groups, but it is not a matter of a single factor causing the devastating disease, Dr. German said.

“Some people with Parkinson’s might have the disease because of exposure to environmental pesticides, but there are also genes known to play a role in the condition,” Dr. German said.

Although the current study points to an interesting link between the pesticide beta-HCH and Parkinson’s, there could be other pesticides involved with the disease, he said.

For example, the pesticide lindane often contains beta-HCH, but lindane breaks down faster. Beta-HCH might simply be a sign that someone was exposed to lindane, with lindane actually causing the damage to the brain, the researchers said.

In future research, Dr. German hopes to test patients from a wider geographical area and to measure pesticide levels in post-mortem brains. He and his team also are collecting blood samples from both patients with Parkinson’s and their spouses to see if a genetic difference might be making the one with Parkinson’s more susceptible to pesticides than the other.

Other UT Southwestern researchers involved in the study were Dr. Padraig O’Suilleabhain, associate professor of neurology; Dr. Ramón Diaz-Arrastía, professor of neurology; and Dr. Joan Reisch, professor of clinical sciences. Researchers from the Robert Wood Johnson Medical School, including lead author Dr. Jason Richardson, and the Environmental and Occupational Health Sciences Institute in New Jersey also participated in the study.

The study was funded by the National Institute of Environmental Health Sciences, the National Institute on Aging, the Dallas Area Parkinsonism Society, Rowe & Co. Inc., the Dallas Foundation and the Michael J. Fox Foundation for Parkinson’s Research.

Visit to learn more about UT Southwestern’s clinical services in neurosciences, including psychiatry.

Aline McKenzie | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

nachricht Breakthrough in Mapping Nicotine Addiction Could Help Researchers Improve Treatment
04.10.2016 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Innovative technique for shaping light could solve bandwidth crunch

20.10.2016 | Physics and Astronomy

Finding the lightest superdeformed triaxial atomic nucleus

20.10.2016 | Physics and Astronomy

NASA's MAVEN mission observes ups and downs of water escape from Mars

20.10.2016 | Physics and Astronomy

More VideoLinks >>>