Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Pegylated liposomal doxorubicin beneficial in metastatic breast cancer

For women with metastatic breast cancer, treatment with an encapsulated form of the drug doxorubicin offers a well-tolerated option for maintenance therapy that delays progression and offers benefits in terms of survival, new results show.

Spanish researchers led by Dr. Emilio Alba have been studying the effects of pegylated liposomal doxorubicin in a group of 155 women who had already been treated with chemotherapy.

At the 33rd Congress of the European Society for Medical Oncology (ESMO) in Stockholm, they present long-term follow-up data showing that 81% of patients prescribed the drug were alive after one year, compared to 66% of those who did not receive the treatment.

The aim of the therapy was to delay progression of disease while inflicting as few side-effects as possible, said Dr. Alba.

“Despite major advances in adjuvant therapy, the number of patients with metastatic breast cancer who are expected to relapse is substantial,” he said. “In this setting the treatment is not curative, but it is important to explore all the available alternatives.”

“In the case of chemotherapy, toxicity is the main drawback. Almost all studies carried out up to now associate maintenance therapy with a longer time-to-progression, and sometimes more overall survival. However, dealing with toxicity forces us to balance benefits and risks.”

“The main finding of this trial was the low toxicity profile of pegylated liposomal doxorubicin at a dose of 40mg/m2. This dose presented no gastrointestinal toxicity, no grade IV alopecia, and grade IV adverse effects such as mucositis or hand-and-foot syndrome (HFS) were lower than 5%. The treatment also presented no cardiotoxicity. The subjective tolerance was very good.”

Women treated with the drug saw a mean increase in time-to-progression of 3.4 months, the researchers found, which is similar to that of new targeted drugs such as trastuzumab or lapanitib. “While a month would probably fall short, a recent survey indicated 51% of oncologists would consider a time-to-progression increase of 3 months as successful,” Dr. Alba said.

“Maintenance therapy is a good option for almost everybody, if we can design effective treatments associated with a good toxicity profile. I think this goal is achieved in the case of pegylated liposomal doxorubicin,” he said.

Vanessa Pavinato | alfa
Further information:

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

TRAPPIST-1 planets provide clues to the nature of habitable worlds

21.03.2018 | Physics and Astronomy

The search for dark matter widens

21.03.2018 | Materials Sciences

Natural enemies reduce pesticide use

21.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>