Roughly one in five adults in northern Europe is believed to suffer from contact allergy to one or more chemicals. The most common is nickel allergy, but many people also suffer from contact allergy to perfumes - even perfume substances that at first glance appear to be harmless can cause allergic reactions. New eczema-provoking allergens are formed by reaction with acid in the ambient air (known as autoxidation) or with skin enzymes.
The study shows geraniol by itself to be only slightly allergenic. However through autoxidation and reaction with skin enzymes, the substance is activated and becomes the closely related allergen geranial. This is the first time these activation pathways have been demonstrated for the substance.
Hagvall's thesis, Formation of Skin Sensitizers from Fragrance Terpenes via Oxidative Activation Routes. Chemical analysis, Structure Elucidation and Experimental Sensitization Studies was defended on the January 30th. The supervisor was Ann-Therese Karlberg, professor of dermatochemistry and head of the research platform Göteborg Science Centre for Molecular Skin Research at the University of Gothenburg.Contact details
Helena Aaberg | idw
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