Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How can metabolic surgery cure diabetes so fast?

14.04.2011
No-one can explain this strange phenomenon. The majority of type 2 diabetics who undergo metabolic surgery recover from diabetes only a few days after the procedure, long before any weight loss has occurred. Now researchers at Lund University Diabetes Center plan to find out what is happening by studying both patients and pigs before and after metabolic surgery.

“Since the recovery from diabetes occurs so early, a process other than weight loss has to be behind it. If we can identify and imitate this process, it could lead to entirely new ways of treating type 2 diabetes”, says Nils Wierup, one of the researchers behind the study.

There is a strong correlation between being overweight or obese and type 2 diabetes, and many diabetics can recover if they lose weight, but this is not the focus of the study. Instead, the focus is on a side effect – the astonishingly fast normalisation of the glucose homeostasis which is seen in 85 per cent of diabetics after metabolic surgery.

Gastric bypass surgery means rerouting food content directly to the small intestine, bypassing the stomach. This means that portion sizes have to become smaller and weight loss in the long term becomes significant.

“We don’t mean that everyone with type 2 diabetes should undergo surgery, but maybe we can learn to achieve the same anti-diabetic effect without the surgery”, says Nils Wierup.

Patients who will be invited to participate in the study are type 2 diabetics who are going to have gastric bypass surgery. They will undergo a variety of tests both before and periodically after the surgery.

The research team will also use pigs, both healthy and diabetic, for experiments that cannot be performed on patients.

“Pigs are suitable because they resemble humans in many ways, including anatomically and in terms of gastrointestinal hormones”, says Nils Wierup, adding that it is possible that a less extensive gastric bypass may have the same dramatic effects.

“In that case the area we need to search will be smaller, and the mechanism we are searching for will be easier to find.”

On the list of suspected factors are changes in the effects of gastrointestinal hormones. It is known that hormone secretion from the gastrointestinal tract plays an important role in glucose homeostasis. Gastric bypass surgery changes the conditions. Metabolic surgery might also drastically change the gastrointestinal bacterial flora since the pH changes, and this should mean that other species of bacteria can establish themselves.

“But it could also be a completely different mechanism. We have to look at a great variety of possible factors”, says Hindrik Mulder, one of the researchers on the team.

For more information: Nils Wierup, +46 40 39 14 14, +46 739 88 36 35
Nils.Wierup@med.lu.se
Hindrik Mulder, +46 40 39 10 23, +46 702 92 69 28; Hindrik.Mulder@med.lu.se

Megan Grindlay | idw
Further information:
http://www.vr.se

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Long-lived storage of a photonic qubit for worldwide teleportation

12.12.2017 | Physics and Astronomy

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>