Some 350 million people live in areas where leishmaniasis can be contracted. Over 90% of cases are reported in India, Bangladesh, Nepal, Sudan, and Brazil. Leishmaniasis is also found in Mexico and elsewhere in South America. There are no effective vaccines to prevent leishmaniasis, and resistance issues greatly reduce the efficacy of conventional medications.
The parasite, which is transmitted to humans during the blood meal of infected sand flies, is internalized via macrophages in the liver, spleen, and bone marrow. However, this parasite manages to alter the normal phagocytosis process (destruction of foreign bodies), resist this process, replicate itself, and infect other macrophages. This resistance process notably involves blocking the normal acidification process within the macrophage by disrupting membrane fusions.To date, few studies have attempted to identify the regulators of these membrane fusions and their role in the phagolysosomal biogenesis process (a compartment where pathogenic microorganisms are usually killed). The work by doctoral candidate Adrien Vinet and Professor Descoteaux shed new light on the biology of Leishmania parasites, particularly the molecular mechanisms by which they manage to outsmart the human immune system.
Albert Descoteaux | EurekAlert!
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy