Some 350 million people live in areas where leishmaniasis can be contracted. Over 90% of cases are reported in India, Bangladesh, Nepal, Sudan, and Brazil. Leishmaniasis is also found in Mexico and elsewhere in South America. There are no effective vaccines to prevent leishmaniasis, and resistance issues greatly reduce the efficacy of conventional medications.
The parasite, which is transmitted to humans during the blood meal of infected sand flies, is internalized via macrophages in the liver, spleen, and bone marrow. However, this parasite manages to alter the normal phagocytosis process (destruction of foreign bodies), resist this process, replicate itself, and infect other macrophages. This resistance process notably involves blocking the normal acidification process within the macrophage by disrupting membrane fusions.To date, few studies have attempted to identify the regulators of these membrane fusions and their role in the phagolysosomal biogenesis process (a compartment where pathogenic microorganisms are usually killed). The work by doctoral candidate Adrien Vinet and Professor Descoteaux shed new light on the biology of Leishmania parasites, particularly the molecular mechanisms by which they manage to outsmart the human immune system.
Albert Descoteaux | EurekAlert!
Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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27.03.2017 | Life Sciences
27.03.2017 | Life Sciences