Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High levels of vitamin D in plasma protects against bladder cancer

31.10.2012
With this study, which combines epidemiological and molecular data, researchers have identified a genetic route that vitamin D could use to prevent this type of cancer

High levels of vitamin D are associated with protection against bladder cancer, according to a multidisciplinary study coordinated by molecular biologists and epidemiologists from the Spanish National Cancer Research Centre (CNIO), the conclusions of which are being published today in the Journal of National Cancer Institute (JNCI) .

The study has been led by Núria Malats, head of the Genetic and Molecular Epidemiology Group, and Francisco X. Real, from the Epithelial Carcinogenesis Group, at the CNIO.

The authors of the study took blood samples from more than 2,000 individuals—including patients with bladder cancer and control subjects free from the disease—in 18 Spanish hospitals, making of this the largest study carried out to-date in this field. "We have seen that those subjects with the highest levels of 25(OH)D3, a stable form of vitamin D in the blood, are those who showed the lowest risk of suffering bladder cancer. These results indicate that high levels of this vitamin are associated with protection from the illness or, similarly, that low levels are associated with a higher risk of suffering from it", says Malats.

"We have also shown, using in vitro molecular analysis, that vitamin D regulates the expression of a protein—FGFR3—that takes part in the development of bladder cancer", adds Real.

According to the study, this protective effect is more obvious in those patients with more aggressive cancers. "We observe that high levels of vitamin D diminish, above all, the risk of developing invasive bladder cancer with low levels of FGFR3; which is to say those cancers with the highest probability of metastizing", says André FS Amaral, first author of the study.

The research results suggest that an increase in the dietary or supplementary intake of this vitamin, or via a controlled increase in sun exposure, might be beneficial for the patient in terms of prevention and treatment.

MORE THAN 11,000 NEW CASES EACH YEAR IN SPAIN

Bladder cancer represents a serious public health problem in many countries, especially Spain, where 11,000 new cases are registered each year, one of the highest rates anywhere in the world. In fact, it is the fourth most frequent type of tumour among Spanish males, after prostate, lung and colorectal cancers.

Following diagnosis, patients are continually observed with different follow-up techniques, among them cystoscopy, which requires the introduction of a small camera via the urethra to observe the bladder lining.

This type of follow-up affects the patients' quality of life and imposes heavy costs on healthcare authorities, thus further increasing the need to improve prevention strategies faced with this type of cancer.

Recent studies relate vitamin D levels with other types of cancer like breast or colon cancer. Despite this research, it is still not clearly understood which molecular routes are used by this vitamin to exercise its protective effect, or the role it plays in other types of tumours.

INTERNATIONAL COLLABORATION
The study took place within the EPICURO/Spanish Bladder Cancer Study, whose aims are to evaluate, among other aspects, both the genetic and non-genetic factors associated with the risk and prognosis for this tumour.

The EPICURO/Spanish Bladder Cancer Study began in 1997 as a collaborative project involving several Spanish institutions coordinated by the Instituto Hospital del Mar de Investigaciones Médicas (Barcelona), and the Division of Cancer Epidemiology and Genetics of the US National Cancer Institute.

Researcher Alberto Muñoz, from the CSIC's Biomedical Research Institute in Madrid has also participated in this specific study on vitamin D.

The research project has been funded by the World Cancer Research Fund (UK); the Intramural Research Program of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (US); the Fondo de Investigación Sanitaria, the Red Temática de Investigación Cooperativa en Cáncer, the AECC's Scientific Foundation, the Consolíder ONCOBIO project and the Madrid regional government in Spain.

Reference article:
Plasma 25-hydroxyvitamin D3 and bladder cancer risk according to tumor stage and FGFR3 status. André FS Amaral, Marinela Méndez-Pertuz, Alberto Muñoz, Debra T Silverman, Yves Allory, Manolis Kogevinas, Josep Lloreta, Nathaniel Rothman, Alfredo Carrato, Manuel Rivas del Fresno, Francisco X Real, and Núria Malats. Journal of National Cancer Institute (2012). doi: 10.1093/jnci/djs444

Nuria Noriega | EurekAlert!
Further information:
http://www.cnio.es

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>