Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High levels of vitamin D in plasma protects against bladder cancer

31.10.2012
With this study, which combines epidemiological and molecular data, researchers have identified a genetic route that vitamin D could use to prevent this type of cancer

High levels of vitamin D are associated with protection against bladder cancer, according to a multidisciplinary study coordinated by molecular biologists and epidemiologists from the Spanish National Cancer Research Centre (CNIO), the conclusions of which are being published today in the Journal of National Cancer Institute (JNCI) .

The study has been led by Núria Malats, head of the Genetic and Molecular Epidemiology Group, and Francisco X. Real, from the Epithelial Carcinogenesis Group, at the CNIO.

The authors of the study took blood samples from more than 2,000 individuals—including patients with bladder cancer and control subjects free from the disease—in 18 Spanish hospitals, making of this the largest study carried out to-date in this field. "We have seen that those subjects with the highest levels of 25(OH)D3, a stable form of vitamin D in the blood, are those who showed the lowest risk of suffering bladder cancer. These results indicate that high levels of this vitamin are associated with protection from the illness or, similarly, that low levels are associated with a higher risk of suffering from it", says Malats.

"We have also shown, using in vitro molecular analysis, that vitamin D regulates the expression of a protein—FGFR3—that takes part in the development of bladder cancer", adds Real.

According to the study, this protective effect is more obvious in those patients with more aggressive cancers. "We observe that high levels of vitamin D diminish, above all, the risk of developing invasive bladder cancer with low levels of FGFR3; which is to say those cancers with the highest probability of metastizing", says André FS Amaral, first author of the study.

The research results suggest that an increase in the dietary or supplementary intake of this vitamin, or via a controlled increase in sun exposure, might be beneficial for the patient in terms of prevention and treatment.

MORE THAN 11,000 NEW CASES EACH YEAR IN SPAIN

Bladder cancer represents a serious public health problem in many countries, especially Spain, where 11,000 new cases are registered each year, one of the highest rates anywhere in the world. In fact, it is the fourth most frequent type of tumour among Spanish males, after prostate, lung and colorectal cancers.

Following diagnosis, patients are continually observed with different follow-up techniques, among them cystoscopy, which requires the introduction of a small camera via the urethra to observe the bladder lining.

This type of follow-up affects the patients' quality of life and imposes heavy costs on healthcare authorities, thus further increasing the need to improve prevention strategies faced with this type of cancer.

Recent studies relate vitamin D levels with other types of cancer like breast or colon cancer. Despite this research, it is still not clearly understood which molecular routes are used by this vitamin to exercise its protective effect, or the role it plays in other types of tumours.

INTERNATIONAL COLLABORATION
The study took place within the EPICURO/Spanish Bladder Cancer Study, whose aims are to evaluate, among other aspects, both the genetic and non-genetic factors associated with the risk and prognosis for this tumour.

The EPICURO/Spanish Bladder Cancer Study began in 1997 as a collaborative project involving several Spanish institutions coordinated by the Instituto Hospital del Mar de Investigaciones Médicas (Barcelona), and the Division of Cancer Epidemiology and Genetics of the US National Cancer Institute.

Researcher Alberto Muñoz, from the CSIC's Biomedical Research Institute in Madrid has also participated in this specific study on vitamin D.

The research project has been funded by the World Cancer Research Fund (UK); the Intramural Research Program of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (US); the Fondo de Investigación Sanitaria, the Red Temática de Investigación Cooperativa en Cáncer, the AECC's Scientific Foundation, the Consolíder ONCOBIO project and the Madrid regional government in Spain.

Reference article:
Plasma 25-hydroxyvitamin D3 and bladder cancer risk according to tumor stage and FGFR3 status. André FS Amaral, Marinela Méndez-Pertuz, Alberto Muñoz, Debra T Silverman, Yves Allory, Manolis Kogevinas, Josep Lloreta, Nathaniel Rothman, Alfredo Carrato, Manuel Rivas del Fresno, Francisco X Real, and Núria Malats. Journal of National Cancer Institute (2012). doi: 10.1093/jnci/djs444

Nuria Noriega | EurekAlert!
Further information:
http://www.cnio.es

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>