Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New generation asthma drug could improve metabolism

06.06.2011
Formoterol, a new generation asthma medication, shows great promise for improving fat and protein metabolism, say Australian researchers, who have tested this effect in a small sample of men. The researchers presented their results on Saturday 4 June 2011 at The Endocrine Society's 93rd Annual Meeting in Boston.

The research team comprises members of Professor Ken Ho's lab from Sydney's Garvan Institute of Medical Research as well as Professor Ric Day, a clinical pharmacologist from St. Vincent's Hospital.

Study leader, endocrinologist Dr Paul Lee, focused his PhD research on how various hormones affect metabolism. Of central importance is a class of hormones called catecholamines, which regulate heart rate, metabolism and breathing.

Formoterol is a synthetic catecholamine, the metabolic effects of which have not previously been studied in people. Therapy doses given to animals, however, have shown that it stimulates metabolism without affecting the heart.

"We have known for a long time that catecholamine influences the way the body handles nutrients, in particular fat and protein," said Lee.

"The generation of drugs before formoterol was exploited in the livestock industry around 20 years ago – to reduce the fat and increase the protein content of meat. Unfortunately, these older drugs also caused a faster heart rate."

"Formoterol is a new generation of this class of medication. It is highly selective for the kind of catecholamine receptors found in the lungs, and not those in the heart."

"The new drug is also more selective for a similar receptor found in muscle and fat. In theory at least, it should have beneficial metabolic effects – like the older class of medication – without affecting the heart."

Lee sourced the drug in its oral form, found the dose needed to give a metabolic effect, and gave it to 8 healthy men over a week.

"Energy metabolism increased by more than 10%, fat burning increased by more than 25%, while protein burning fell by 15%," he said.

"So although whole body metabolism increased, these men burned fat while reducing the burning of protein. That's a good thing because in the long run these effects may lead to a loss in fat mass and an increase in muscle.

"In this study, all 8 subjects tolerated the medication well – without any significant increase in heart rate."

The next step will be to test the drug over a longer period in a larger sample of people to determine if the beneficial effects translate into improvement in body composition, health and function.

Alison Heather | EurekAlert!
Further information:
http://researchaustralia.org/

More articles from Health and Medicine:

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>