Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene variants protect against relapse after treatment for Hepatitis C

13.03.2014

Researchers at the Sahlgrenska Academy, University of Gothenburg, have identified a gene, which explains why certain patients with chronic hepatitis C do not experience relapse after treatment. The discovery may contribute to more effective treatment.

More than 100 million humans around the world are infected with hepatitis C virus. The infection gives rise to chronic liver inflammation, which may result in reduced liver function, liver cirrhosis and liver cancer. Even though anti-viral medications often efficiently eliminate the virus, the infection recurs in approximately one fifth of the patients.

Prevents incorporation in DNA

... more about:
»DNA »HCV »Hepatitis »ITPA »RNA »activity »function »infections »liver »relapse

Martin Lagging and co-workers at the Sahlgrenska Academy have studied an enzyme called inosine trifosfatas (ITPase), which normally prevents the incorporation of defective building blocks into RNA and DNA.

Unexpectedly they found that the gene encoding for ITPase (ITPA) had significance for the treatment outcome in chronic hepatitis C virus infection.

Five times lower risk

Earlier studies had shown that approximately one third of all people carry variants of the ITPA gene that result in reduced ITPase activity. The research team at the Sahlgrenska Academy showed that patients with these gene variants exhibited a more than a five times lower risk of experiencing relapse after treatment.

Relapse a significant problem

The study encompassed over 300 patients and was carried out in cooperation with hepatitis researchers in several Nordic countries.

- Relapse after completed treatment is a significant problem in chronic hepatitis C, and the results may contribute to explaining why the infection recurs in many patients. Our hypothesis is that a low ITPase activity results in defective nucleotides being incorporated into the virus RNA, which makes the virus unstable, Martin Lagging said.

Important to other virus infections

According to Martin Lagging, the discovery may also have significance for other virus infections.

- A medication that interferes with the enzyme’s activity could have a broad antiviral effect, but this must be further investigated in future studies.

The article Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3 was published online in the journal Hepatology on 13 January 2014.

Link to the article: http://bit.ly/1nc4ly0

Contact:
Martin Lagging, researcher at The Sahlgrenska Academy, University of Gothenburg
martin.lagging@medfak.gu.se

Weitere Informationen:

http://sahlgrenska.gu.se/english/news_and_events/news/News_Detail/?languageId=10...

Krister Svahn | idw - Informationsdienst Wissenschaft

Further reports about: DNA HCV Hepatitis ITPA RNA activity function infections liver relapse

More articles from Health and Medicine:

nachricht Scientists pinpoint bladder cancer patients who could benefit from 'tumor-softening' treatment
31.07.2014 | Cancer Research UK

nachricht Monoamine oxidase A: biomarker for postpartum depression
31.07.2014 | Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Counting down to FEBS-EMBO 2014 in Paris, France

29.07.2014 | Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

 
Latest News

Mapping the optimal route between 2 quantum states

31.07.2014 | Physics and Astronomy

Monoamine oxidase A: biomarker for postpartum depression

31.07.2014 | Health and Medicine

Saving Seeds the Right Way Can Save the World's Plants

31.07.2014 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>