Research published in BioMed Central’s open access journal Critical Care describes how applying a bacterial solution in place of normal antiseptics is effective in preventing the most common cause of ventilator-associated pneumonia (VAP).
Bengt Klarin from the University Hospital in Lund, Sweden, led a team of researchers who carried out a randomised, controlled trial in fifty patients, comparing friendly bacteria to the normally used antiseptic chlorhexidine (CHX). Klarin said, “We hypothesised that swabbing the mouth with probiotics would be an effective (and microbiologically attractive) method of reducing pathogenic oral microorganisms in intubated, mechanically ventilated, critically ill patients.”
VAP is a common complication in patients on breathing machines. It occurs when harmful bacteria from the mouth, throat or breathing tube are inhaled into the lungs. Because most people on ventilation are sedated or unable to communicate, initial symptoms of pneumonia can be difficult to spot. According to Klarin, “VAP is connected with longer intensive care and hospital stays, additional costs and high mortality. The risk of developing this condition increases by 1% with each additional day of mechanical ventilation.”
The authors found that the probiotic treatment was as effective as the antiseptic. Use of the bacteria has other advantages; there are common side effects associated with CHX use in oral care, including tooth discoloration, irritation and, very occasionally, serious allergic reactions. Moreover, CHX diluted by saliva and represents an additional risk for the creation of resistant strains. The authors claim that the L. plantarum 299 solves these problems, “It is not likely to incorporate resistance genes or plasmids or to transfer genetic material. Consequently it does not contribute to the development of antibiotic-resistant strains. As the bacteria adhere to the oral mucosa, they are able to counteract potentially pathogenic bacteria around the clock, which is superior to the fairly short-term effect of orally applied chemical agents.”
L. plantarum is normally present in saliva and is also commonly found in fermented food products like pickles and sauerkraut. The authors found no negative side effects of using it in this study.
Graeme Baldwin | alfa
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences