Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fetal membrane transplantation prevents blindness

27.04.2012
Transplanting tissue from newborn fetal membranes prevents blindness in patients with a devastating disease called Stevens-Johnson syndrome, a Loyola University Medical Center study has found.
The study by senior author Charles Bouchard, MD, and colleagues is published online ahead of print in the journal Cornea.

Stevens-Johnson syndrome (SJS) is a disorder in which skin and mucous membranes, including the eye surface, react severely to a medication or infection. SJS causes painful skin blisters, and as the disease progress, the skin sloughs off as if the patient had been burned. A more severe form of the disease, involving more than 30 percent of the body surface, is called toxic epidermal necrolysis (TEN).

Between 50 percent and 81 percent of SJS/TEN patients experience eye problems, ranging from mild dry eye to severe scarring that can cause blindness.
Loyola researchers studied a relatively new eye treatment for SJS/TEN patients called amniotic membrane transplantation. Amniotic membrane is part of the fetal membranes that surround and protect the baby in the womb, and have natural therapeutic properties. When placed on the eye, amniotic membrane can help aid healing, decrease inflammation and minimize scarring. (Amniotic membrane is donated by a consenting mother following the birth of her baby.)

SJS/TEN has an earlier acute stage and a later chronic stage. Previous studies have found that amniotic membrane transplantation is effective in the chronic stage. The Loyola case-control study is one of the largest studies to examine the effect of amniotic membrane transplantation in the early, acute stage. The first case reported in a medical journal was done by a Loyola ophthalmologist, Dr. Thomas John.

Researchers examined the records of 128 SJS/TEN patients admitted to the Loyola University Medical Center Burn Intensive Care Unit from 1998 to 2010. Some patients died and others did not have adequate followup. Among the remaining patients, researchers compared recent patients with mild, moderate and severe disease who received amniotic membrane transplantation with similar patients who did not receive amniotic membrane treatment because it was not available at the time.

Thirteen of the recent patients underwent amniotic membrane transplantation on a total of 25 eyes during the early stage of the disease, and 17 patients (33 eyes) received standard medical management but no transplantation. After three months, only 4.3 percent of the eyes treated with amniotic membrane transplantation were legally blind (vision worse than 20/200 when corrected). By comparison, 35 percent of the eyes treated with medical management alone were legally blind.

Researchers wrote: "Our results support the use of early amniotic membrane transplantation, within the first three to five days, over the entire ocular surface. . . If the amniotic membrane is placed more than one week after the onset of the disease, the beneficial effects may be reduced."

Researchers are now examining the levels of a variety of inflammatory mediators in the skin, blood, eye and mouth in patients with SJS/TENS to better understand the cause of this devastating disease, and to develop better treatments.

Drs. Charles Bouchard and Amy Lin, MD, did the amniotic membrane transplants in the study. Bouchard is chairman and Lin is an assistant professor in the Department of Ophthalmology of Loyola University Chicago Stritch School of Medicine.

Co-authors of the study, all in Loyola's Department of Ophthalmology, are Maylon Hsu, MD, (first author), Anupam Jayaram, MD and Ruth Verner, BS.

Jim Ritter | EurekAlert!
Further information:
http://www.lumc.edu

Further reports about: Medical Wellness Ophthalmology SJS amniotic amniotic membrane fetal mucous membrane

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>