Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Non-drug treatments help alleviate symptoms of treatment-induced menopause in breast cancer patients

22.03.2012
Researchers from The Netherlands have found that the menopausal symptoms caused by giving chemotherapy or hormonal therapy to younger women with breast cancer can be ameliorated considerably through the use of cognitive behavioural therapy (CBT)[1] and physical exercise (PE).

These interventions can be effective in dealing with such distressing symptoms as hot flushes, night sweats, vaginal dryness, weight gain, urinary incontinence and sexual problems, a researcher will tell the 8th European Breast Cancer Conference (EBCC-8) today (Thursday).

The researchers studied 422 breast cancer patients with an average age of 48 years recruited from 14 hospitals from the Amsterdam and Rotterdam regions of the Netherlands. They were randomly assigned to four groups – CBT alone, PE alone, CBT and PE combined – and a control group. Compared with the control group, all those patients who received one or both interventions showed an overall decrease in the levels of menopausal symptoms, in addition to reporting an increase in sexuality and an improvement in physical functioning. These positive effects were still apparent after six months.

"To our knowledge, this is the first study to investigate the efficacy of these two interventions specifically in women who have experienced acute, treatment-induced menopause," Dr. Marc van Beurden from The Netherlands Cancer Institute, Amsterdam, The Netherlands, will say. "This is a very important issue for the quality of life of younger breast cancer patients. Unlike healthy women starting the menopause, they are unable to take hormone replacement therapy to alleviate their symptoms. There are other drugs available, but they are only moderately effective and have troublesome side-effects."

The CBT programme consisted of six weekly group sessions of 90 minutes each, including relaxation exercises. The primary focus of the CBT was on hot flushes and night sweats, but other symptoms were also addressed. The PE programme was a 12-week, individually tailored, home-based and self-directed exercise programme of two and a half to three hours per week. Initial training and follow-up was provided by physiotherapists. The goal was to exercise at an intensity level that achieved a target heart rate.

The researchers believe that the CBT reduces stress levels and helps women cope effectively with the symptoms they are experiencing. Physical exercise is intended to reduce hot flushes through an effect on the thermoregulatory system. "There was already evidence that both interventions were effective in women undergoing the natural menopause," says Dr. van Beurden's colleague, Dr. Hester van Oldenburg. "We are pleased to have established that they also work in women with induced menopause, which is significantly more difficult for patients to deal with both because it is caused by cancer treatment, which is distressing in itself, and because the symptoms often come on so quickly that there is little or no time to get used to them."

Patients said that participation in the CBT programme made them more aware of their symptoms and how to deal with them. "Before, I more or less accepted them unconsciously. Now I'm more alert about my symptoms, their effect, and possible ways to cope with them. By sharing my experiences with others, I've learned to put my symptoms in perspective and to cope with them," said one participant.

While the evidence that the interventions worked was convincing, compliance with them was poor, the researchers say. In the case of CBT, it was difficult to schedule the group sessions at a time that was convenient for women who often had both work and parenting responsibilities. The frequency and intensity of the PE programme was also a challenge for many women.

"We think that we have made an important step forward in improving the quality of life of these patients," Dr. van Beurden will say. "Based on input from patients, we are now developing an internet-based version of the CBT programme. We hope that this will further increase the accessibility and convenience of the interventions and lead to more women benefiting from their results."

Professor David Cameron, from the University of Edinburgh (Edinburgh, UK), and chair of EBCC-8 said: "Menopausal symptoms can often be an added burden of side effects for younger women undergoing treatment for breast cancer. This study is important as it offers evidence that there is a way to intervene to make this less of a problem for women, thus allowing them to get on with their lives after curative therapy for breast cancer."

[1] Cognitive Behavioural Therapy is an action-oriented form of psychosocial therapy and psycho-education that focuses on changing an individual's thoughts (cognitive patterns) in order to change his or her behaviour and emotional state. In the current study, CBT was combined with relaxation techniques.

[2] The research was funded by the Dutch Cancer Society, the Integral Cancer Centre Amsterdam, the Pink Ribbon Foundation, and Polar Electro Nederland.

Abstract no: 199, Thursday 10.30 hrs, Proffered Paper session "Implications of Adjuvant Therapy and Toxicity", Hall D

Mary Rice | EurekAlert!
Further information:
http://www.ecco-org.eu

Further reports about: CBT EBCC-8 breast cancer cancer patients hot flushes night sweats quality of life

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>