Every tenth woman is afflicted with breast cancer during her lifetime.The diagnosis and treatment of a patient involves the collaboration of a wide range of specialists.
To improve this situation, VPH-PRISM partners are developing software for X-ray, MRI images, ultrasound, and histology from biopsies, to provide a unified display to spatially superimpose, measure, and manipulate these images. Especially helpful would be the ability to characterize the area surrounding a tumor more accurately. The project will aim to answer the questions: has this tissue changed to such a degree that it must be removed with the tumor during the operation, or can a more local excision, exposing the patient to a less invasive operation, be performed without the risk of recurrence?
To accomplish this, tissue sample pathology slides must be digitized. However, digitization generates large amounts of data, which pathologists can only partially inspect. To solve this, VPH-PRISM experts are also developing software that automatically preselects and preprocesses the data, thereby facilitating the work of the pathologist. If the venture is successful, experts estimate that digital pathology will promote a breakthrough in breast cancer care similar to the effect that the widespread introduction of mammography had on early detection that has occurred over the last 15 years.
The project will explore how a deep understanding of tissue microstructure, gleaned from histology, can aid interpretation of X-ray, MRI, and ultrasound images. Additionally challenging is the presentation of tissue sample images alongside MRI and X-ray images. Experts using computationally intensive algorithms must guarantee that multiple data sets fit perfectly together. Only in this manner can tissue parameters gathered using different scalings be spatially correlated and hence superimposed.The goal is a software tool that supports clinicians when choosing therapy. Patient data should be grouped automatically according to shared criteria. This allows the software to provide clues for optimal chemotherapy, for instance, if a patient with particular tissue characteristics has been assigned to a particular group. This could prove useful for monitoring the progress of therapy more accurately: Is the tumor degenerating as quickly as expected when a patient undergoes a certain type of chemotherapy? If not, then the doctor could cease ineffective therapy in a timely fashion and provide the patient with alternative drugs.
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy