The aortic valve study was led by Sabine Bleiziffer, MD, consultant cardiac surgeon, German Heart Center Munich, Munich, Germany, and will be presented as a poster abstract (TCT-111) on Tuesday, September 22 between 8:00 a.m. and 10:00 a.m. in Hall D of The Moscone Center.
"Transcatheter aortic valve implantation with the self-expandable prosthesis is an effective and durable treatment for patients with aortic stenosis not eligible for surgical aortic valve replacement," said Dr. Bleiziffer.
Between June 2007 and April 2009, 179 aortic valve prostheses were implanted in non-surgical candidates via a number of different routes: transfemoral (164 patients), transapical (5 patients), subclavian artery (7 patients), and ascending aorta (3 patients). Patients were a mean age of 81 ± 7y, with a mean STS score of 19 ± 11% and symptomatic high-grade aortic stenosis (mean valve orifice area 0.7 ± 0.2cm², mean aortic gradient 48 ± 18 mm Hg).
Periprocedural complications included femoral access site complications in 13% of the patients, dialysis for postoperative renal failure in 8%, neurologic events in 7%, and permanent pacemaker implantation in 26%. 30 day-, 6 months-, and 1 year-survival was 88%, 78%, and 78%, respectively.
Freedom from bleeding events, thromboembolic events, structural valve deterioration and prosthestic endocarditis was 83%, 97%, 99% and 97% at one year. Non-structural valve deterioration or valve thrombosis did not occur. Mean aortic gradient decreased to 11 ± 4 mm Hg (valve size 26) and 12 ± 4 mm Hg (valve size 29), and valve orifice area increased to 1.4 ± 0.4cm² (valve size 26) and 1.5 ± 0.3cm² without change up to one-year follow-up.
The study concluded that multiple vascular access sites are feasible for implantation of the prosthesis because of the small diameter of the delivery sheath. Periprocedural complications are considerable but related to the high risk patient population. Mid-term valve-related complications are exceptionally low and the gradient release after prosthesis implantation is stable up to one year of follow-up.
"A close and careful follow-up of patients treated with the new technology of transcatheter valve implantation including history of valve-related complications and echocardiographic assessment is crucial to approve the quality of the technique and to redefine indications for future patients," said Dr. Bleiziffer.
About CRF and TCT
The Cardiovascular Research Foundation (CRF) is an independent, academically focused nonprofit organization dedicated to improving the survival and quality of life for people with cardiovascular disease through research and education. Since its inception in 1991, CRF has played a major role in realizing dramatic improvements in the lives of countless numbers of patients by establishing the safe use of new technologies and therapies in the subspecialty of interventional cardiology and endovascular medicine.
Transcatheter Cardiovascular Therapeutics (TCT) is the annual scientific symposium of the Cardiovascular Research Foundation. TCT gathers leading medical researchers and clinicians from around the world to present and discuss the latest developments in the field of interventional cardiology and vascular medicine.
Judy Romero | EurekAlert!
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences