Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New clues to the cause of Alzheimer’s disease

30.06.2011
Researchers at the Sahlgrenska Academy, University of Gothenburg, have identified a series of novel proteins in human cerebrospinal fluid.

The proteins, which carry specific sugar molecules, are found in greater concentrations in patients with dementia caused by Alzheimer’s disease than in patients with dementia caused by other diseases. This gives hope for new forms of treatment in the future.

Göran Larson is a professor at the Sahlgrenska Academy and one of the authors of the article published in the revered journal Proceedings of the National Academy of Sciences USA (PNAS).

“When it comes to the link to Alzheimer’s, we’re thinking first and foremost of the possibilities to use these molecules as markers for an early and reliable diagnosis, but also, of course, of what role these molecules may play in the development and course of the disease.”

These new molecules give researchers another way of thinking of the mechanisms behind Alzheimer’s disease. Larson and his research team are already working with other researchers at the Sahlgrenska Academy and Chalmers University of Technology to develop new analytical techniques for measuring the concentrations of these molecules in cerebrospinal fluid. The aim is to try to make the analyses more sensitive, as well as simpler, cheaper and more accessible so that they can be used as routine clinical assays when investigating dementia.

“Dementia is a major and growing problem not just for healthcare but for society as a whole since more people are getting older and older, and the single largest risk factor for Alzheimer’s is just that – old age,” says Larson. “There isn’t currently any effective pharmaceutical treatment for Alzheimer’s, but if this discovery can contribute to an early diagnosis then medicines that slow the progression of the disease can be tried before the dementia gets too severe.

“If we can link the formation of these molecules to the disease mechanisms behind Alzheimer’s, then there’s hope that we can also develop new drugs that can affect the course of this serious disease.”

ALZHEIMER’S DISEASE
With more than 100,000 people affected in Sweden, Alzheimer’s is one of the most common diseases of our society. Caused by changes in the brain tissue, the disease predominantly affects the memory and often leads to an earlier death. Alzheimer’s disease results in not only considerable suffering for patients and their families, but also in huge costs to society.
For more information, please contact:
Göran Larson, professor/consultant at the Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, tel: +46 (0)31 342 1330, mobile: +46 (0)70 620 216, e-mail: goran.larson@clinchem.gu.se
Kaj Blennow, professor of clinical neurochemistry, Sahlgrenska Academy, tel: +46 (0)31 343 1791, mobile: +46 (0)704 972 730, e-mail: kaj.blennow@neuro.gu.se

Henrik Zetterberg, professor of neurochemistry, Sahlgrenska Academy, tel: +46 (0)31 343 0142, mobile: +46 (0)768 672 647, e-mail: henrik.zetterberg@clinchem.gu.se

Journal: Proceedings of the National Academy of Sciences USA (PNAS)
Title of article: Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid

Authors: Adnan Halim, Gunnar Brinkmalm, Ulla Rüetschi, Ann Westman-Brinkmalm, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Göran Larson and Jonas Nilsson

Helena Aaberg | idw
Further information:
http://www.gu.se

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>