The proteins, which carry specific sugar molecules, are found in greater concentrations in patients with dementia caused by Alzheimer’s disease than in patients with dementia caused by other diseases. This gives hope for new forms of treatment in the future.
Göran Larson is a professor at the Sahlgrenska Academy and one of the authors of the article published in the revered journal Proceedings of the National Academy of Sciences USA (PNAS).
“When it comes to the link to Alzheimer’s, we’re thinking first and foremost of the possibilities to use these molecules as markers for an early and reliable diagnosis, but also, of course, of what role these molecules may play in the development and course of the disease.”
These new molecules give researchers another way of thinking of the mechanisms behind Alzheimer’s disease. Larson and his research team are already working with other researchers at the Sahlgrenska Academy and Chalmers University of Technology to develop new analytical techniques for measuring the concentrations of these molecules in cerebrospinal fluid. The aim is to try to make the analyses more sensitive, as well as simpler, cheaper and more accessible so that they can be used as routine clinical assays when investigating dementia.
“Dementia is a major and growing problem not just for healthcare but for society as a whole since more people are getting older and older, and the single largest risk factor for Alzheimer’s is just that – old age,” says Larson. “There isn’t currently any effective pharmaceutical treatment for Alzheimer’s, but if this discovery can contribute to an early diagnosis then medicines that slow the progression of the disease can be tried before the dementia gets too severe.
“If we can link the formation of these molecules to the disease mechanisms behind Alzheimer’s, then there’s hope that we can also develop new drugs that can affect the course of this serious disease.”
Henrik Zetterberg, professor of neurochemistry, Sahlgrenska Academy, tel: +46 (0)31 343 0142, mobile: +46 (0)768 672 647, e-mail: firstname.lastname@example.orgJournal: Proceedings of the National Academy of Sciences USA (PNAS)
Authors: Adnan Halim, Gunnar Brinkmalm, Ulla Rüetschi, Ann Westman-Brinkmalm, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Göran Larson and Jonas Nilsson
Helena Aaberg | idw
New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University
Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences