Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New clues to the cause of Alzheimer’s disease

30.06.2011
Researchers at the Sahlgrenska Academy, University of Gothenburg, have identified a series of novel proteins in human cerebrospinal fluid.

The proteins, which carry specific sugar molecules, are found in greater concentrations in patients with dementia caused by Alzheimer’s disease than in patients with dementia caused by other diseases. This gives hope for new forms of treatment in the future.

Göran Larson is a professor at the Sahlgrenska Academy and one of the authors of the article published in the revered journal Proceedings of the National Academy of Sciences USA (PNAS).

“When it comes to the link to Alzheimer’s, we’re thinking first and foremost of the possibilities to use these molecules as markers for an early and reliable diagnosis, but also, of course, of what role these molecules may play in the development and course of the disease.”

These new molecules give researchers another way of thinking of the mechanisms behind Alzheimer’s disease. Larson and his research team are already working with other researchers at the Sahlgrenska Academy and Chalmers University of Technology to develop new analytical techniques for measuring the concentrations of these molecules in cerebrospinal fluid. The aim is to try to make the analyses more sensitive, as well as simpler, cheaper and more accessible so that they can be used as routine clinical assays when investigating dementia.

“Dementia is a major and growing problem not just for healthcare but for society as a whole since more people are getting older and older, and the single largest risk factor for Alzheimer’s is just that – old age,” says Larson. “There isn’t currently any effective pharmaceutical treatment for Alzheimer’s, but if this discovery can contribute to an early diagnosis then medicines that slow the progression of the disease can be tried before the dementia gets too severe.

“If we can link the formation of these molecules to the disease mechanisms behind Alzheimer’s, then there’s hope that we can also develop new drugs that can affect the course of this serious disease.”

ALZHEIMER’S DISEASE
With more than 100,000 people affected in Sweden, Alzheimer’s is one of the most common diseases of our society. Caused by changes in the brain tissue, the disease predominantly affects the memory and often leads to an earlier death. Alzheimer’s disease results in not only considerable suffering for patients and their families, but also in huge costs to society.
For more information, please contact:
Göran Larson, professor/consultant at the Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, tel: +46 (0)31 342 1330, mobile: +46 (0)70 620 216, e-mail: goran.larson@clinchem.gu.se
Kaj Blennow, professor of clinical neurochemistry, Sahlgrenska Academy, tel: +46 (0)31 343 1791, mobile: +46 (0)704 972 730, e-mail: kaj.blennow@neuro.gu.se

Henrik Zetterberg, professor of neurochemistry, Sahlgrenska Academy, tel: +46 (0)31 343 0142, mobile: +46 (0)768 672 647, e-mail: henrik.zetterberg@clinchem.gu.se

Journal: Proceedings of the National Academy of Sciences USA (PNAS)
Title of article: Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid

Authors: Adnan Halim, Gunnar Brinkmalm, Ulla Rüetschi, Ann Westman-Brinkmalm, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Göran Larson and Jonas Nilsson

Helena Aaberg | idw
Further information:
http://www.gu.se

More articles from Health and Medicine:

nachricht Usher syndrome: Gene therapy restores hearing and balance
25.09.2017 | Institut Pasteur

nachricht MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The fastest light-driven current source

Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.

Graphene is up to the job

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Goodbye, login. Hello, heart scan

26.09.2017 | Information Technology

The material that obscures supermassive black holes

26.09.2017 | Physics and Astronomy

Ageless ears? Elderly barn owls do not become hard of hearing

26.09.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>