Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

What causes chronic bowel disease?

06.11.2012
Europe-wide network for investigating irritable bowel syndrome headed by Heidelberg University Hospital/European Science Foundation provides 500,000 euros in funding for understanding causes, improving options for diagnosis and treatment

For the first time, scientists from 19 European countries have joined forces to form an interdisciplinary network for investigating the causes of irritable bowel syndrome and improving options for diagnosis and treatment.


Intestinal mucosa cells under the microscope: Serotonin receptors are stained green, nerve fibers are stained red.

Image: Heidelberg University Hospital

The European Science Foundation is funding the network, entitled GENIEUR (Genes in Irritable Bowel Syndrome Europe) and headed by biologist Dr. Beate Niesler of Heidelberg University Hospital’s Institute of Human Genetics, providing 500,000 euros over the next four years. Some five million patients in Germany suffer from symptoms including stomachache, constipation or diarrhea, frequently accompanied by other illnesses such as migraine, anxiety or depression, and often have these symptoms for years. To date, only symptoms of the disease can be treated.

Over 70 research groups are participating in the GENIEUR network. “GENIEUR is the world’s first large-scale interdisciplinary approach to investigating irritable bowel syndrome,” explained Niesler, head of the Neurogastrointestinal and Psychiatric Disorders Research Group at the Department of Molecular Human Genetics and spokesperson for the network. “Our goal is not just to identify characteristic changes in a patient’s genome, but to also test an array of possible interactions, for instance, the interactions between and lifestyle, diet, allergies, mental illness, pain syndromes, past infections or changes in intestinal flora,” Niesler said. It is also important to define uniform diagnostic criteria and subgroups of the syndrome, so that patients can benefit from a suitable treatment more quickly, she added. Besides gastroenterologists and human geneticists, the network also includes nutritionists, psychiatrists, immunologists, physiologists, neurobiologists, microbiologists, bioinformatic specialists and epidemiologists.

Certain changes in the genome promote irritable bowel syndrome
Irritable bowel syndrome (IBS) is one of the most common diseases of the intestinal tract. As much as 15 percent of Europe’s population suffers from the disease, which strongly impacts the patients’ overall well-being and quality of life. Depending on the type and severity of the symptoms, they are barely able to leave the house, cannot work or pursue their hobbies. Since little has been known about the causes of irritable bowel syndrome to date, diagnosis and treatment have been difficult. Currently, diagnosis is performed by ruling out other diseases, while for treatment trial and error is the only method available. Remedies that alleviate symptoms in some patients, such as special anti-inflammatory drugs, are completely ineffective for others, so that finding the right treatment can be a long and-drawn-out process that for some patients is not successful.

In 2008, the team headed by Niesler discovered that the nervous disturbances of the bowel can be exacerbated by changes in the genome. In patients who have IBS with diarrhea, the genetic blueprint for certain receptors in the bowel has often been changed. The receptors are located at the surface of the intestinal cells and bind the hormone serotonin. If they are changed, signal transmission in the bowel is disturbed. These research findings provided an initial approach for targeted drug therapy. “However, the receptors have changed in only some of the patients. We assume that several variants of this disease exist that can be attributed to different molecular causes in each case,” Niesler said.
New diagnostic criteria intended to simplify treatment

In order to detect these molecular factors, the teams are now establishing the first biobank with stool and tissue specimens from patients and healthy controls and are systematically collecting patient data. In so doing, they are aiming to identify reliable biomarkers and compile a catalog of criteria to precisely assign patients to individual subgroups. “If physicians can reliably assign their patients to a certain group, they can better predict which treatments are most likely to benefit the patients.” This may spare patients a long period of suffering,” Niesler explained. In addition, the teams plan to use genetic analyses of the subgroups to obtain information on the mechanism by which each variation of the syndrome evolves and on possible treatment approaches.

More information is available on the Web:
http://www.GENIEUR.eu

Participating centers in German with contact addresses:
http://www.RDS-net.uni-hd.de
http://www.ag-niesler.uni-hd.de

Contact
Dr. Beate Niesler
Institute of Human Genetics, Department of Molecular Human Genetics
Heidelberg University Hospital
Tel.: +49 06221 56-35274
Email: beate.niesler@med.uni-heidelberg.de

Heidelberg University Hospital and Medical Faculty:
Internationally recognized patient care, research, and teaching
Heidelberg University Hospital is one of the largest and most prestigious medical centers in Germany. The Medical Faculty of Heidelberg University belongs to the internationally most renowned biomedical research institutions in Europe. Both institutions have the common goal of developing new therapies and implementing them rapidly for patients. With about 11,000 employees, training and qualification is an important issue. Every year, around 550,000 patients are treated on an inpatient or outpatient basis in more than 50 clinics and departments with 2,000 beds. Currently, about 3,600 future physicians are studying in Heidelberg; the reform Heidelberg Curriculum Medicinale (HeiCuMed) is one of the top medical training programs in Germany.

Requests by journalists:
Dr. Annette Tuffs
Head of Public Relations and Press Department
University Hospital of Heidelberg and
Medical Faculty of Heidelberg
Im Neuenheimer Feld 672
D-69120 Heidelberg
Germany
phone: +49 6221 / 56 45 36
fax: +49 6221 / 56 45 44
e-mail: annette.tuffs(at)med.uni-heidelberg.de

Dr. Annette Tuffs | idw
Further information:
http://www.klinikum.uni-heidelberg.de/presse

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>