Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

What causes chronic bowel disease?

06.11.2012
Europe-wide network for investigating irritable bowel syndrome headed by Heidelberg University Hospital/European Science Foundation provides 500,000 euros in funding for understanding causes, improving options for diagnosis and treatment

For the first time, scientists from 19 European countries have joined forces to form an interdisciplinary network for investigating the causes of irritable bowel syndrome and improving options for diagnosis and treatment.


Intestinal mucosa cells under the microscope: Serotonin receptors are stained green, nerve fibers are stained red.

Image: Heidelberg University Hospital

The European Science Foundation is funding the network, entitled GENIEUR (Genes in Irritable Bowel Syndrome Europe) and headed by biologist Dr. Beate Niesler of Heidelberg University Hospital’s Institute of Human Genetics, providing 500,000 euros over the next four years. Some five million patients in Germany suffer from symptoms including stomachache, constipation or diarrhea, frequently accompanied by other illnesses such as migraine, anxiety or depression, and often have these symptoms for years. To date, only symptoms of the disease can be treated.

Over 70 research groups are participating in the GENIEUR network. “GENIEUR is the world’s first large-scale interdisciplinary approach to investigating irritable bowel syndrome,” explained Niesler, head of the Neurogastrointestinal and Psychiatric Disorders Research Group at the Department of Molecular Human Genetics and spokesperson for the network. “Our goal is not just to identify characteristic changes in a patient’s genome, but to also test an array of possible interactions, for instance, the interactions between and lifestyle, diet, allergies, mental illness, pain syndromes, past infections or changes in intestinal flora,” Niesler said. It is also important to define uniform diagnostic criteria and subgroups of the syndrome, so that patients can benefit from a suitable treatment more quickly, she added. Besides gastroenterologists and human geneticists, the network also includes nutritionists, psychiatrists, immunologists, physiologists, neurobiologists, microbiologists, bioinformatic specialists and epidemiologists.

Certain changes in the genome promote irritable bowel syndrome
Irritable bowel syndrome (IBS) is one of the most common diseases of the intestinal tract. As much as 15 percent of Europe’s population suffers from the disease, which strongly impacts the patients’ overall well-being and quality of life. Depending on the type and severity of the symptoms, they are barely able to leave the house, cannot work or pursue their hobbies. Since little has been known about the causes of irritable bowel syndrome to date, diagnosis and treatment have been difficult. Currently, diagnosis is performed by ruling out other diseases, while for treatment trial and error is the only method available. Remedies that alleviate symptoms in some patients, such as special anti-inflammatory drugs, are completely ineffective for others, so that finding the right treatment can be a long and-drawn-out process that for some patients is not successful.

In 2008, the team headed by Niesler discovered that the nervous disturbances of the bowel can be exacerbated by changes in the genome. In patients who have IBS with diarrhea, the genetic blueprint for certain receptors in the bowel has often been changed. The receptors are located at the surface of the intestinal cells and bind the hormone serotonin. If they are changed, signal transmission in the bowel is disturbed. These research findings provided an initial approach for targeted drug therapy. “However, the receptors have changed in only some of the patients. We assume that several variants of this disease exist that can be attributed to different molecular causes in each case,” Niesler said.
New diagnostic criteria intended to simplify treatment

In order to detect these molecular factors, the teams are now establishing the first biobank with stool and tissue specimens from patients and healthy controls and are systematically collecting patient data. In so doing, they are aiming to identify reliable biomarkers and compile a catalog of criteria to precisely assign patients to individual subgroups. “If physicians can reliably assign their patients to a certain group, they can better predict which treatments are most likely to benefit the patients.” This may spare patients a long period of suffering,” Niesler explained. In addition, the teams plan to use genetic analyses of the subgroups to obtain information on the mechanism by which each variation of the syndrome evolves and on possible treatment approaches.

More information is available on the Web:
http://www.GENIEUR.eu

Participating centers in German with contact addresses:
http://www.RDS-net.uni-hd.de
http://www.ag-niesler.uni-hd.de

Contact
Dr. Beate Niesler
Institute of Human Genetics, Department of Molecular Human Genetics
Heidelberg University Hospital
Tel.: +49 06221 56-35274
Email: beate.niesler@med.uni-heidelberg.de

Heidelberg University Hospital and Medical Faculty:
Internationally recognized patient care, research, and teaching
Heidelberg University Hospital is one of the largest and most prestigious medical centers in Germany. The Medical Faculty of Heidelberg University belongs to the internationally most renowned biomedical research institutions in Europe. Both institutions have the common goal of developing new therapies and implementing them rapidly for patients. With about 11,000 employees, training and qualification is an important issue. Every year, around 550,000 patients are treated on an inpatient or outpatient basis in more than 50 clinics and departments with 2,000 beds. Currently, about 3,600 future physicians are studying in Heidelberg; the reform Heidelberg Curriculum Medicinale (HeiCuMed) is one of the top medical training programs in Germany.

Requests by journalists:
Dr. Annette Tuffs
Head of Public Relations and Press Department
University Hospital of Heidelberg and
Medical Faculty of Heidelberg
Im Neuenheimer Feld 672
D-69120 Heidelberg
Germany
phone: +49 6221 / 56 45 36
fax: +49 6221 / 56 45 44
e-mail: annette.tuffs(at)med.uni-heidelberg.de

Dr. Annette Tuffs | idw
Further information:
http://www.klinikum.uni-heidelberg.de/presse

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Better model of water under extreme conditions could aid understanding of Earth's mantle

21.06.2018 | Earth Sciences

What are the effects of coral reef marine protected areas?

21.06.2018 | Life Sciences

The Janus head of the South Asian monsoon

21.06.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>