These bacteria carry a special protein sequence, the so-called PARF motif, on their surface. In the renowned journal PLoS ONE Singh Chhatwal and his colleague Patric Nitsche-Schmitz of the Helmholtz Centre for Infection Research (HZI) in Braunschweig illustrate the role played by PARF in the development of rheumatic heart disease. With this knowledge they are developing a test system that is able to recognise and prevent the disease at an early stage.
"PARF means 'peptide associated with rheumatic fever'," explains Nitsche-Schmitz. "It is a small section from a bacterial surface protein , which is used by the streptococcus to adhere to our cells and cause disease." Rheumatic fever develops from harmless sore throats amongst children in India, Australia and Africa in particular. The reason: inadequate medical treatment: if children with a streptococcus infection in the throat receive no or inadequate antibiotic treatment, then the surviving bacteria with the PARF sequence on their surface will adhere to their collagen.
Collagen is present throughout the body – as a major component of bone and cartillage it determines shape and structure of our body and it strengthens the connective tissue of the skin, the heart valves and blood vessels with its high resistance to tensile forces. Adhesion of PARF-bearing streptococci to collagenconfuses our immune system and our body's defence system not only targets the bacteria, but also healthy and vital collagen. The auto-immune disease rheumatic fever breaks out. If this in turn also fails to be treated correctly, the consequence is rheumatic heart disease: the heart valves, rich in collagen, become inflamed and cease to function.
Overall, only around five percent of all throat infections with streptococci result in an auto-immune disease. In order to filter out these five percent and treat them at an early stage, the Braunschweig infection researchers are developing a simple test strip that reacts to the PARF motif. "We hope that this will soon give us a test system that we can use for examination of children on a routine basis," says Singh Chhatwal: "This would save the lives of a lot of children."
Dr. Bastian Dornbach | EurekAlert!
Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
24.10.2016 | Power and Electrical Engineering
24.10.2016 | Life Sciences
24.10.2016 | Life Sciences