Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The body rids itself of damage when it really matters

20.09.2011
Although the body is constantly replacing cells and cell constituents, damage and imperfections accumulate over time.

Cleanup efforts are saved for when it really matters. Researchers from the University of Gothenburg, Sweden, are able to show how the body rids itself of damage when it is time to reproduce and create new life.

‘I have a daughter. She is made of my cells yet has much less cellular damage than my cells. Why didn’t she inherit my cells including the damaged proteins? That’s the process I’m interested in,’ says Malin Hernebring from the Department of Cell- and Molecular Biology at the University of Gothenburg.

A few days after conception, the cells in the embryo all look the same – they are unspecified stem cells that can develop into any bodily cell type. As the process of cell specification (differentiation) begins, they go from being able to keep dividing infinitely to being able to do so only a limited number of times. This is when they start cleansing themselves.

‘Quite unexpectedly we found that the level of protein damage was relatively high in the embryo’s unspecified cells, but then it decreased dramatically. A few days after the onset of cell differentiation, the protein damage level had gone down by 80-90 percent. We think this is a result of the damaged material being broken down.’

In the past, researchers have believed that the body keeps cells involved in reproduction isolated and protected from damage. Now it has been shown that these types of cells go through a rejuvenation process that rids them of the inherited damage.

Some types of protein damage in the body increase with age. Although all the necessary information is stored in the DNA, something keeps the body from using it to keep repairing the body.

‘These types of protein damages are what make us appear old, like wrinkles around the eyes. While wrinkles are relatively harmless, serious problems may arise elsewhere in the body. I’m thinking of age-related diseases like Parkinson’s, Alzheimer’s, type 2 diabetes and cancer.’

Malin Hernebring can show that the damaged proteins in the cells are probably broken down by molecular machines called proteasomes. The proteasome activity increases considerably during the initial steps of embryonic stem cell differentiation in mice. Deciphering this rejuvenation process helps us better understand what ageing really is, which in turn may help us slow it down and also prevent the occurrence and ill effects of age-related diseases.

Contact:
Malin Hernebring
031- 786 2576
malin.hernebring@cmb.gu.se
Department of Cell- and Molecular Biology
University of Gothenburg
Medicinaregatan 9E
413 90 Göteborg, Sweden

Helena Aaberg | idw
Further information:
http://www.gu.se/

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>